期刊
JOURNAL OF AFFECTIVE DISORDERS
卷 287, 期 -, 页码 1-7出版社
ELSEVIER
DOI: 10.1016/j.jad.2021.03.020
关键词
Sex difference; Clinical symptoms; Cognitive deficit; Multiple linear regression; depression
资金
- National Natural Science Foundation of China [81,871,066]
- Jiangsu Provincial key research and development program [BE2018609, BE2019675]
- Jiangsu Provincial Medical Innovation Team of the Project of Invigorating Health Care through Science, Technology and Education [CXTDC2016004]
- Medical Science and Technology development Foundation, Jiangsu Commission of Health [K2019011]
The study found significant differences in the association between symptom profiles and cognitive impairment in male and female patients with depressive disorder. Female patients performed better in information processing speed, while different symptom profiles were independently associated with specific cognitive functions in male and female patients.
Objective: Depressive disorder (DD) is a heterogeneous disease with sex differences in symptom profiles and cognitive performance. However, sex differences in cognitive dysfunction associated with different symptom profiles have received little systematic study. This study aimed to explore the association between clinical symptoms and cognitive deficits in patients with DD. Methods: A cohort of 222 hospitalized patients with DD (males/females = 114/108) and 173 healthy controls (males/females = 80/93) were enrolled. Cognitive function was measured using a comprehensive neuropsychological battery. Depression was assessed using the 17-item Hamilton Rating Scale for Depression (HAMD-17). According to different genders, the relationship between symptom profiles and cognitive deficits was identified using partial correlation analysis and multiple regression analysis. Results: Patients with DD performed significantly worse than healthy controls in all cognitive domains investigated (all p < 0.05). Remarkably, female patients scored better than male patients on information processing speed (p < 0.05). Multivariate regression analyses showed that the retardation factor score was independently associated with attention and cognitive flexibility, and the sleep disturbance factor score was independently associated with information processing speed in male patients. Furthermore, the anxiety/somatization factor score was independently associated with working memory in female patients. Conclusion: In the present study, we showed that significant sex differences in the association between symptom profiles and cognitive impairment are present in DD patients. Understanding how DD patients? clinical features and cognitive performance are linked from a sex perspective may have clinical implications for predicting and interfering with the outcome of depression.
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