期刊
JOURNAL OF AFFECTIVE DISORDERS
卷 281, 期 -, 页码 384-389出版社
ELSEVIER
DOI: 10.1016/j.jad.2020.12.050
关键词
Major Depressive Disorder; QIDS-SR; Galectin-3; Dallas Heart Study; Inflammation
资金
- National Center for Advancing Translational Sciences of the National Institutes of Health [UL1TR001105]
- Donald W. Reynolds Cardiovascular Clinical Research Center
Galectin-3 is a novel and useful inflammatory biomarker that may be associated with severity of depressive symptoms. Female sex, smoking status, and BMI were identified as positive predictors of depression severity, while age, years of education, race/ethnicity were found to be negative predictors of depressive symptom severity.
Major depressive disorder is associated with pro-inflammatory markers, such as cytokines TNF-alpha, IL-6, IL-1 beta, and C-reactive protein. Galectin-3 is a novel emerging biomarker with pro-inflammatory properties. It is a saccharide binding protein distributed throughout many tissues with varying functions and is a predictor of poor outcomes in patients with heart failure and stroke. However, its role as a predictor in depressive symptom severity remains undefined. Data from the community-based Dallas Heart Study (n = 2554) were examined using a multiple linear regression analysis to evaluate the relationship between galectin-3 and depressive symptom severity as assessed with Quick Inventory of Depressive Symptomatology Self-Report (QIDS-SR) scores. Additional covariates included age, sex, race/ethnicity, body mass index (BMI), years of education, serum creatinine, history of diabetes, and smoking history. Galectin-3 levels statistically significantly predicted QIDS-SR depressive symptom severity (beta = 0.055, p = .015). Female sex, smoking status, and BMI were found to be statistically significant positive predictors of depression severity, while age, years of education, non-Hispanic White race, and Hispanic ethnicity were negative predictors of depressive symptom severity. In this large sample, higher galectin-3 levels were associated with higher levels of depressive symptoms. The findings suggest that galectin-3 may be a new and useful inflammatory biomarker associated with depression.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据