期刊
JOURNAL OF AFFECTIVE DISORDERS
卷 282, 期 -, 页码 41-45出版社
ELSEVIER
DOI: 10.1016/j.jad.2020.12.098
关键词
Carotenoids; Beta-cryptoxanthin; Depression; Dose-response; NHANES
资金
- Agricultural Research Service, U.S. Department of Agriculture
This study suggests that increasing intake of beta-cryptoxanthin-rich foods may protect against depressive symptoms, as a significant inverse association was found between dietary beta-cryptoxanthin intake and depression prevalence. However, further prospective studies are needed before dietary recommendations can be made.
Background: The data for effect of dietary specific carotenoids on depression are limited and controversial. Thus, this study aimed to examine the relationship between dietary carotenoids intakes and the prevalence of depressive symptoms. Methods: In the 2015-2016 United States National Health and Nutrition Examination Survey, 4,105 adults with complete data of dietary intake and assessment of depressive symptoms are enrolled. Dietary intake was assessed through two 24-h dietary recall interviews. Depression symptoms were assessed using the nine-item Patient Health Questionnaire. We used logistic regression to assess the relationship between diet carotenoids intake and the prevalence of depressive symptoms, adjusting for the main potential confounders. In addition, daily dietary carotenoids intake was adjusted for daily total energy intake based on the nutrient density model. Results: We found a significant inverse association between dietary beta-cryptoxanthin intake and depressive symptoms, with lowest prevalence in the third tertile (OR: 0.65, 95% CI: 0.47-0.90, p for trend < 0.001). Dose-response analyses revealed that the prevalence of depressive symptoms decreased with increasing intakes of beta-cryptoxanthin when reached the point above 110 ug/1000 Kcal. No such association was found for alphacarotene, beta-carotene, lycopene, and lutein/zeaxanthin. Conclusions: Increase the intake of beta-cryptoxathin-rich foods might protect from depressive symptoms. Further prospective studies are requested before dietary recommendation.
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