期刊
JOURNAL OF AFFECTIVE DISORDERS
卷 282, 期 -, 页码 401-406出版社
ELSEVIER
DOI: 10.1016/j.jad.2020.12.083
关键词
Depression; Body mass index; Overweight; Cognition; Functioning
资金
- Fundacao de Amparoa Pesquisa do Estado do Rio Grande do Sul (FAPERGS)
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
The study aimed to assess the independent effects of depression and excess body weight on cognition and functioning in young adults. The results showed that both depression and excess body weight have negative impacts on cognition and functioning, with a cumulative effect when they coexist. The complex interactions between these factors are important for developing preventive and therapeutic strategies.
Objectives: The purpose of this study is to assess the independent effects of depression and excess body weight (EBW) on cognition and functioning in a community sample of young adults. Methods: This was a cross-sectional of 943 young adults. The diagnosis of a current depressive episode was performed using the Mini International Neuropsychiatric Interview (MINI). Cognition and functioning were assessed using the Montreal Cognitive Assessment (MoCA) and the Functional Assessment Short Test (FAST), respectively. The EBW was defined as BMI >= 25.0 kg/m(2). The independent main effects of depression and EBW, as well as the analysis interaction were performed using two-way analysis of covariance (ANCOVA). Results: The total sample comprised 943 adults, with 75 (8.0%) individuals diagnosed with a current depressive episode and 493 (52,6%) with EBW. Of the 75 subjects with depression, 40 were identified with EBW comorbidity. Subjects with depression and EBW comorbidity reported greater cognitive and functional impairment, as compared to individuals with depression without EBW. There was a significant interaction between depression and EBW on MoCA total (p<0.001) as well as FAST total (p=0.010), work (p=0.002), cognition (p=0.023), finances (p=0.032) and relationships domains (p=0.008). Conclusions: The adverse effects of depression and EBW are independent and cumulative with respect to cognition and functioning of individuals. The understanding of the complex interactions between cognition, functioning, EBW and depression are important for development of preventive and therapeutic strategies.
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