期刊
ISRAEL JOURNAL OF CHEMISTRY
卷 61, 期 3-4, 页码 231-233出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ijch.202000104
关键词
Chemosensing; fluorescence; amino-sugars; hydrogen-bonding; phosphoric-acids
资金
- Boehringer Ingelheim Foundation
- Fonds der Chemischen Industrie
- DFG
- Projekt DEAL
This study presents the application of multidentate BINOL-based phosphoric acids for fluorescence-based chemosensing of amino sugars. A novel synthetic protocol was developed for isomerically pure phosphoric acid monoesters, which were found to be effective hosts for binding amino sugars and discriminating between them through fluorescence detection.
In this account, we describe the application of a series of multidentate BINOL-based phosphoric acids for the fluorescence-based chemosensing of amino sugars. To this end, we developed a novel synthetic protocol for three isomerically pure phosphoric acid monoesters of the type ArOP(O)(OH)(2). These were investigated with respect to their binding towards amino sugars (glucosamine, galactosamine and mannosamine) in comparison to the previously reported diesters of the type (ArO)(2)P(O)(OH). We could find that the diesters show no significant binding, while the monoesters can be used as hosts for amino sugars. Indeed, one host selectively binds to galactosamine, while a second host binds both glucosamine and mannosamine. This allows the fluorescence-based detection and discrimination of the amino sugars by a novel class of phosphate-based supramolecular hosts.
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