4.3 Article

Mechanism of hypertensive crisis during energy device ablation of the adrenal gland: An experimental animal study

期刊

INTERNATIONAL JOURNAL OF UROLOGY
卷 28, 期 5, 页码 598-604

出版社

WILEY
DOI: 10.1111/iju.14517

关键词

adrenal gland; adrenal medulla; electrocoagulation; hypertension crisis; surgical hemostasis

资金

  1. AMCO Incorporated Funding Source: Medline

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The study elucidated the mechanism of hypertensive crisis during energy device ablation of the adrenal gland, revealing that the crisis is caused by the release of catecholamines due to heat damage to the adrenal medulla, rather than the type of energy device used.
Objective To elucidate the mechanism of hypertensive crisis during energy device ablation of the adrenal gland. Methods Electrocoagulation on the adrenal glands of six pigs was carried out with the same energy device (VIO300D) using four methods: (i) monopolar coagulation; (ii) monopolar soft coagulation using IO-advanced ball-type electrodes; (iii) bipolar soft coagulation by pinching; and (iv) bipolar soft coagulation by non-pinching (surface contact) using Bipolar forceps Premium. After electrocoagulation for 5 s, blood pressure and pulse changes were monitored, and adrenal hormones were measured from a central vein. The adrenal glands were removed, and the degree of tissue damage was scored histologically. Results Hypertensive crisis occurred with electrocoagulation of the adrenal gland by the monopolar coagulation, monopolar soft coagulation and bipolar soft coagulation pinching methods. Blood pressure did not change with the bipolar soft coagulation non-pinching method. Pathologically, tissue damage to the adrenal medulla was associated with elevated blood pressure and adrenaline and noradrenaline release. Conclusions Hypertensive crisis caused by energy device ablation to the adrenal gland is caused by the release of catecholamines due to heat damage to the adrenal medulla rather than the type of energy device. Proper use of an energy device that does not cause thermal degeneration of the medulla is required to prevent hypertensive crisis.

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