期刊
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
卷 71, 期 9, 页码 677-691出版社
TAYLOR & FRANCIS AS
DOI: 10.1080/00914037.2021.1876058
关键词
Nanofiber scaffold; nanoparticle; PHB; self-assembly; soybean protein
资金
- Tianjin Science Technology Research Funds of China [19JCZDJC37500]
In this study, soybean protein nanoparticles were incorporated into poly(hydroxybutyrate) electrospun nanofiber scaffolds, which showed improved cytocompatibility and potential for biomedical applications through various characterization tests including SEM, EDS, XPS, FTIR, XRD, DMA, WCA, tensile test, water uptake capacity measurements, biodegradation tests in simulated body fluid, and cell culture studies.
In this study, soybean protein nanoparticles (SPN) modified poly(hydroxybutyrate) (PHB) electrospun nanofiber scaffold is fabricated by a facile two-step method combination of PHB electrospinning and SPN evaporation-induced self-assembly. The surface characteristics, structure and properties are investigated by SEM, EDS, XPS, FTIR, XRD, DMA, WCA, tensile test and water uptake capacity measurements. To characterize biodegradability and cytocompatibility, biodegradation tests are performed in simulated body fluid with and without lysozyme and cell cultures are carried out using NIH3T3 mouse fibroblast cells by in vitro studies. The as-obtained SPN-modified PHB nanofiber scaffold presents better cytocompatibility and is more suitable for biomedical applications.
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