Polyvinyl alcohol based-drug delivery systems for cancer treatment

Polyvinyl alcohol (PVA) is a biodegradable semicrystalline synthetic polymer that has been used for biomedical applications for several years. In the pharmaceutical area, PVA has been widely used to prepare solid dispersions to improve the solubility of drugs. Furthermore, it has been demonstrated that PVA is highly biocompatible and non-toxic in in-vitro and in-vivo studies. Several reports provided in this review suggest a promising strategy for cancer treatment. Thus far, the current therapy includes a combination of surgery, chemotherapy, and radiotherapy, the effectivity can be limited due to the heterogeneous manifestations of the disease, dose-related toxicity, and side effects. A promising strategy is the implementation of a targeted therapy using hydrogels, microparticles, or nanoparticles (NPs), capable of encapsulating, protecting, transporting, and targeted administration of a therapeutic agent. Considering the relevance of the PVA in conjunction with their copolymers, it has become a promising biodegradable material to build novel functional composites used in the fabrication of hydrogels, microparticles, nanoparticles, and nanocomposites for drug delivery systems in cancer treatment.

Automated summary

Polyvinyl alcohol (PVA) is a biodegradable synthetic polymer with high biocompatibility and non-toxicity, widely used in biomedical and pharmaceutical applications. Utilizing PVA to prepare hydrogels, microparticles, or nanoparticles for cancer treatment shows promising results in improving drug solubility, targeted drug delivery, and reducing toxicity and side effects. The combination of PVA with copolymers has emerged as a viable strategy for building novel functional composites for drug delivery systems in cancer treatment.