Targeting strategies of oral nano-delivery systems for treating inflammatory bowel disease

Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory disorder of gastrointestinal tract with rising incidence. Established treatments of IBD are characterized by significantly adverse effects, insufficient therapeutic efficacy. Employing the oral nano-drug delivery systems for targeted therapy is capable of effectively avoiding systematic absorption and increasing local drug concentration, consequently leading to decreased adverse effects and improved therapeutic outcomes. This review gives a brief profile of pathophysiological considerations in terms of developing disease-directed drug delivery systems, then focuses on mechanisms and strategies of current oral nano-drug delivery systems, including size-, enzyme-, redox-, pH-, ligand-receptor-, mucus-dependent systems, and proposes the future directions of managements for IBD.

Automated summary

Inflammatory bowel disease is a chronic inflammatory disorder of the gastrointestinal tract with increasing incidence. Current treatments are associated with significant adverse effects and limited efficacy. Using oral nano-drug delivery systems for targeted therapy can reduce systemic absorption, increase local drug concentration, and improve therapeutic outcomes.