Biodegradable dendritic Boltorn™ nanoconstructs: A promising avenue for cancer theranostics

The family of Boltorn (TM) H40 dendrimers is an imperative subclass of hyperbranched biodegradable polymers (HBPs), which has received mounting attention as a result of its inimitable chemical, physical and biodegradable properties. These properties embrace three-dimensional dendrimeric nanoarchitecture to avert tanglement between polymer branches, adequate spatial cavities for increased encapsulation of guest molecules, good solubility as well as low viscosity to improve processability, and a huge number of surface functional groups for chemical manipulations. Similarly, low toxicity, non-immunogenicity, and natural biodegradation are significant and critical advantages in therapeutic applications as compared to other dendritic polymers. All these characteristics of Boltorn (TM) H40 are of pronounced importance for planning and developing advanced targeted cargo delivery carriers for cancer therapy. The present review highlights the applications of Boltorn (TM) H40 HBPs for the transport of chemotherapeutic agents to manage various types of cancers.

Automated summary

The family of Boltorn™ H40 dendrimers, as an imperative subclass of hyperbranched biodegradable polymers, has unique chemical, physical, and biodegradable properties that make it ideal for advanced drug delivery systems, especially in cancer therapy. Its three-dimensional dendrimeric nanoarchitecture, low toxicity, and natural biodegradation are key advantages for targeted cargo delivery carriers.