4.7 Article

Exploration and evaluation of dynamic dose-control platform for pediatric medicine based on Drop-on-Powder 3D printing technology

期刊

出版社

ELSEVIER
DOI: 10.1016/j.ijpharm.2021.120201

关键词

Drop-on-powder 3D printing technology (DoP); Theophylline (TP); Metoprolol tartrate (MT); Pediatric patient; Dynamic dose-control platform; Personalized medicines

资金

  1. National Science and Technology Major Project [2017ZX09201003-011]
  2. China Pharmaceutical Association-YiLing Biomedical Innovation Project
  3. JingXin Pharmaceutical Co., Ltd. (Zhejiang, China)

向作者/读者索取更多资源

This study explored the possibility of using a DoP technology-based desktop 3D printer to build a dynamic dose-control platform for personalized medicines, which demonstrated high accuracy in drug dose regulation. It is particularly suitable for pediatric patients who require flexible dose adjustments.
Patient responses to doses vary widely, and affording limited doses to such a diverse population will inevitably yield unsatisfactory therapeutic effects and even adverse effects. In Particular, there is an urgent demand for a dynamic dose-control platform for pediatric patients, many of whom require diverse doses and flexible dose adjustments. The aim of this study was to explore the possibility of using a drop-on-powder (DoP) technology-based desktop 3D printer to build a dynamic dose-control platform for theophylline (TP) and metoprolol tartrate (MT). In addition, the impact of drug loading patterns on the accuracy of dose regulation was also assessed. All of the printed tablets exhibited good mechanical properties and satisfactory structural integrity. On printing tablets with target drug doses, the accuracy was in the range of 91.2 similar to 108% with a small variation coefficient in the range of 0.5 similar to 3.2%. Compared with traditional divided-dose methods, drop-on-powder 3D printing technology exhibited higher accuracy in dose regulation, but had less impact on the in vitro drug release behavior. The results in this work clearly indicate the possibility and ability of DoP technology as a promising method for constructing a dynamic dose-control platform for the fabrication of personalized medicines for pediatric patients.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据