期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 597, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.ijpharm.2021.120207
关键词
Heparin; PLGA nanoparticles; Sericin/Gelatin Scaffold; Wound dressing; Wet electrospinning
Skin regeneration is a crucial issue in tissue engineering, and developing effective biomaterials for enhanced regeneration while meeting the healing requirements is a challenge. This study encapsulated heparin in PLGA nanoparticles and incorporated them into Ser/Gel nanofibers to create a controlled release system promoting skin tissue regeneration. Sericin addition slowed down scaffold degradation, and the scaffold with a Ser/Gel ratio of 1/2 was considered the most promising candidate due to its proper fiber morphology, high water retention, and low degradation degree.
Skin regeneration is one of the most important issues in tissue engineering. Research on more effective biomaterials that will enhance regeneration while enabling requirements of a healing skin site is an important challenge in skin tissue engineering. In this study, heparin was encapsulated in Poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) which were then incorporated into Sericin/Gelatin (Ser/Gel) nanofibers during the electrospinning process in order to develop a combined system that has controlled release approach, besides the ability to help the regeneration of skin tissue by the involvement of biopolymers; gelatin, and sericin. The loading capacity and heparin encapsulation efficiency in the nanoparticles were determined as 30.04 mg/g of polymer and 60%, respectively. Cumulative release of heparin from NPs for 1 week was faster than from NPs loaded gelatin scaffolds and from dual protein (Ser/Gel) scaffolds with ratios: 1/7 and 1/2 (approximately 85%, 65%, 55%, and 40%, respectively). Sericin addition slowed down the degradation properties of the scaffold. The scaffold having a Ser/Gel ratio (1/2) was found as the most promising candidate because of its proper fiber morphology, high water retention, and low degradation degree.
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