期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 597, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.ijpharm.2021.120342
关键词
Electrospraying; Microcapsules; Probiotics; Mucoadhesion; Alginate; Chitosan
资金
- European Union's Erasmus + programme
- Doctoral School of Food Science, Szent Istvan University, Hungary
The study focused on the importance of prolonged gastrointestinal retention for probiotics delivery. Different formulations of alginate microparticles were prepared using electrospray technique, with chitosan-coated microparticles showing the highest mucoadhesive property. A novel in vitro wash-off mucoadhesion test setup was successfully validated for evaluating the performance of these probiotic formulations.
Besides viability protection, a sufficiently prolonged gastrointestinal retention of probiotics has emerged as critically important in improving the functional effectiveness of gastrointestinal delivery of these microorganisms. In this work, we formulated pure, resistant starch-reinforced and chitosan-coated alginate microparticles using an electrospray technique and evaluated their performance as mucoadhesive probiotic formulations for gastrointestinal delivery. In addition, we designed and successfully validated a novel experimental set-up of in vitro wash-off mucoadhesion test, using a portable and low-cost USB microscope for fluorescence imaging. In our test, pure chitosan microparticles (positive control) exhibited the greatest mucoadhesive property, whereas the alginate-resistant starch ones (negative control) were the least retentive on a gastric mucosa. These electrosprayed formulations were spherically shaped, with a size range of 30-600 mu m (60-1300 mu m with chitosan coating). Moreover, model probiotic Lactobacillus plantarum loaded in alginate-starch formulations was better protected against simulated gastric conditions than in alginate ones, but not better than in the chitosan-coated ones.
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