期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 22, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/ijms22052351
关键词
probiotics; gut microbiota; dysbiosis; gut– brain axis; anorexia nervosa; bulimia nervosa; binge-eating disorder; anxiety
资金
- Red de Salud Materno-Infantil y del Desarrollo (SAMID) [RD12/0026/0003, RD16/0022/0002]
- Instituto de Salud Carlos III [PI16/00566, PI19/01853]
- FEDER
Anxiety and eating disorders can alter gut microbiota, impacting neurological processes. Factors such as diet, lifestyle, infections, and antibiotic treatment can also affect the gut-brain axis. Probiotic supplementation can partially restore the gut microbiota imbalance in patients with anxiety or eating disorders.
Anxiety and eating disorders produce a physiological imbalance that triggers alterations in the abundance and composition of gut microbiota. Moreover, the gut-brain axis can be altered by several factors such as diet, lifestyle, infections, and antibiotic treatment. Diet alterations generate gut dysbiosis, which affects immune system responses, inflammation mechanisms, the intestinal permeability, as well as the production of short chain fatty acids and neurotransmitters by gut microbiota, which are essential to the correct function of neurological processes. Recent studies indicated that patients with generalized anxiety or eating disorders (anorexia nervosa, bulimia nervosa, and binge-eating disorders) show a specific profile of gut microbiota, and this imbalance can be partially restored after a single or multi-strain probiotic supplementation. Following the PRISMA methodology, the current review addresses the main microbial signatures observed in patients with generalized anxiety and/or eating disorders as well as the importance of probiotics as a preventive or a therapeutic tool in these pathologies.
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