期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 22, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/ijms22062785
关键词
calmodulin; calcium; plasma membrane Ca2+-ATPase; sarco; endoplasmic Ca2+-ATPase; secretory pathway Ca2+-ATPase; mental diseases
资金
- National Science Centre [2019/33/B/NZ4/00587]
- Medical University of Lodz [503/6-086-02/503-61-001]
Calcium plays crucial roles in mammalian neurons, with its concentration tightly regulated by calcium pumps to prevent detrimental consequences. These pumps not only transport calcium ions but also have tissue-specific functionalities and are regulated by calmodulin.
Calcium in mammalian neurons is essential for developmental processes, neurotransmitter release, apoptosis, and signal transduction. Incorrectly processed Ca2+ signal is well-known to trigger a cascade of events leading to altered response to variety of stimuli and persistent accumulation of pathological changes at the molecular level. To counterbalance potentially detrimental consequences of Ca2+, neurons are equipped with sophisticated mechanisms that function to keep its concentration in a tightly regulated range. Calcium pumps belonging to the P-type family of ATPases: plasma membrane Ca2+-ATPase (PMCA), sarco/endoplasmic Ca2+-ATPase (SERCA) and secretory pathway Ca2+-ATPase (SPCA) are considered efficient line of defense against abnormal Ca2+ rises. However, their role is not limited only to Ca2+ transport, as they present tissue-specific functionality and unique sensitive to the regulation by the main calcium signal decoding protein-calmodulin (CaM). Based on the available literature, in this review we analyze the contribution of these three types of Ca2+-ATPases to neuropathology, with a special emphasis on mental diseases.
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