期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 22, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/ijms22052236
关键词
trogocytosis; oncologic trogocytosis; amoebic trogocytosis; cell clearance; tumor surveillance; tumor evasion; chimeric antigen receptor T lymphocyte; antibody-dependent cell-mediated cytotoxicity; antigen modification; immune plasticity
资金
- Ministry of Science Technology [101-2314-B-002 -142 -MY3, 106-2314-B-002 -215 -MY2]
- National Taiwan University Hospital [109-55]
Trogocytosis refers to the rapid bidirectional transfer of surface membrane fragments and associated proteins between cells. Its biological actions include information exchange, cell clearance, and immunoregulation.
The term trogocytosis refers to a rapid bidirectional and active transfer of surface membrane fragment and associated proteins between cells. The trogocytosis requires cell-cell contact, and exhibits fast kinetics and the limited lifetime of the transferred molecules on the surface of the acceptor cells. The biological actions of trogocytosis include information exchange, cell clearance of unwanted tissues in embryonic development, immunoregulation, cancer surveillance/evasion, allogeneic cell survival and infectious pathogen killing or intercellular transmission. In the present review, we will extensively review all these aspects. In addition to its biological significance, aberrant trogocytosis in the immune system leading to autoimmunity and immune-mediated inflammatory diseases will also be discussed. Finally, the prospective investigations for further understanding the molecular basis of trogocytosis and its clinical applications will also be proposed.
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