相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Cryo-EM Structure of the Human Cannabinoid Receptor CB2-Gi Signaling Complex
Changrui Xing et al.
CELL (2020)
Cholesterol impacts chemokine CCR5 receptor ligand-binding activity
Pierre Calmet et al.
FEBS JOURNAL (2020)
Activation of μ-δ opioid receptor heteromers inhibits neuropathic pain behavior in rodents
Vinod Tiwari et al.
PAIN (2020)
Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR
Laura M. Wingler et al.
SCIENCE (2020)
Cholesterol interaction motifs in G protein-coupled receptors: Slippery hot spots?
Parijat Sarkar et al.
WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE (2020)
Structure of formylpeptide receptor 2-Gi complex reveals insights into ligand recognition and signaling
Youwen Zhuang et al.
NATURE COMMUNICATIONS (2020)
Structural basis of ligand binding modes at the human formyl peptide receptor 2
Tong Chen et al.
NATURE COMMUNICATIONS (2020)
Nanobody-enabled monitoring of kappa opioid receptor states
Tao Che et al.
NATURE COMMUNICATIONS (2020)
Cholesterol-mediated oligomerization pathways of serotonin G-coupled receptor 5-HT2C
Luca Massaccesi et al.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)
Lipid rafts as a therapeutic target
Dmitri Sviridov et al.
JOURNAL OF LIPID RESEARCH (2020)
Intrinsic dynamics is evolutionarily optimized to enable allosteric behavior
Yan Zhang et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2020)
Crystal structure of the human oxytocin receptor
Yann Waltenspuehl et al.
SCIENCE ADVANCES (2020)
Structural basis of CXC chemokine receptor 2 activation and signalling
Kaiwen Liu et al.
NATURE (2020)
Single-molecule analysis reveals agonist-specific dimer formation of μ-opioid receptors
Jan Moeller et al.
NATURE CHEMICAL BIOLOGY (2020)
Structure and selectivity engineering of the M1 muscarinic receptor toxin complex
Shoji Maeda et al.
SCIENCE (2020)
The operational model of allosteric modulation of pharmacological agonism
Jan Jakubik et al.
SCIENTIFIC REPORTS (2020)
Interfacial Binding Sites for Cholesterol on G Protein-Coupled Receptors
Anthony G. Lee
BIOPHYSICAL JOURNAL (2019)
Conformational Complexity and Dynamics in a Muscarinic Receptor Revealed by NMR Spectroscopy
Jun Xu et al.
MOLECULAR CELL (2019)
24S-Hydroxycholesterol Is Associated with Agitation Severity in Patients with Moderate-to-Severe Alzheimer's Disease: Analyses from a Clinical Trial with Nabilone
Myuri Ruthirakuhan et al.
JOURNAL OF ALZHEIMERS DISEASE (2019)
Cryo-EM structure of the native rhodopsin dimer in nanodiscs
Dorothy Yanling Zhao et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2019)
Toward G protein-coupled receptor structure-based drug design using X-ray lasers
Andrii Ishchenko et al.
IUCRJ (2019)
Elucidating the active δ-opioid receptor crystal structure with peptide and small-molecule agonists
Tobias Claff et al.
SCIENCE ADVANCES (2019)
Membrane cholesterol depletion reduces downstream signaling activity of the adenosine A2A receptor
Claire McGraw et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2019)
Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex
Kaavya Krishna Kumar et al.
CELL (2019)
Structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors
Anastasiia Gusach et al.
NATURE COMMUNICATIONS (2019)
Role of membrane cholesterol in differential sensitivity of muscarinic receptor subtypes to persistently bound xanomeline
Alena Randakova et al.
NEUROPHARMACOLOGY (2018)
Molecular details of dimerization kinetics reveal negligible populations of transient μ-opioid receptor homodimers at physiological concentrations
Derya Meral et al.
SCIENTIFIC REPORTS (2018)
Viral GPCR US28 can signal in response to chemokine agonists of nearly unlimited structural degeneracy
Timothy F. Miles et al.
ELIFE (2018)
Structural determinants of 5-HT2B receptor activation and biased agonism
John D. McCorvy et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2018)
Exploring the structure and stability of cholesterol dimer formation in multicomponent lipid bilayers
Asanga Bandara et al.
JOURNAL OF COMPUTATIONAL CHEMISTRY (2017)
Modulation of Chemokine Receptor Function by Cholesterol: New Prospects for Pharmacological Intervention
Daniel F. Legler et al.
MOLECULAR PHARMACOLOGY (2017)
Trends in GPCR drug discovery: new agents, targets and indications
Alexander S. Hauser et al.
NATURE REVIEWS DRUG DISCOVERY (2017)
X-ray structures of endothelin ETB receptor bound to clinical antagonist bosentan and its analog
Wataru Shihoya et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2017)
Membrane cholesterol access into a G-protein-coupled receptor
Ramon Guixa-Gonzalez et al.
NATURE COMMUNICATIONS (2017)
X-ray structures of endothelin ETB receptor bound to clinical antagonist bosentan and its analog
Wataru Shihoya et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2017)
Identification of Two New Cholesterol Interaction Sites on the A2A Adenosine Receptor
Eric Rouviere et al.
BIOPHYSICAL JOURNAL (2017)
Crystal Structure of an LSD-Bound Human Serotonin Receptor
Daniel Wacker et al.
CELL (2017)
Interaction of G protein coupled receptors and cholesterol
Gerald Gimpl
CHEMISTRY AND PHYSICS OF LIPIDS (2016)
Controlling the Dissociation of Ligands from the Adenosine A2A Receptor through Modulation of Salt Bridge Strength
Elena Segala et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Crystal structures of the M1 and M4 muscarinic acetylcholine receptors
David M. Thal et al.
NATURE (2016)
Intracellular allosteric antagonism of the CCR9 receptor
Christine Oswald et al.
NATURE (2016)
Dynamic Cholesterol-Conditioned Dimerization of the G Protein Coupled Chemokine Receptor Type 4
Kristyna Pluhackova et al.
PLOS COMPUTATIONAL BIOLOGY (2016)
Mechanism of allosteric regulation of β2-adrenergic receptor by cholesterol
Moutusi Manna et al.
ELIFE (2016)
Molecular dynamics simulations of GPCR-cholesterol interaction: An emerging paradigm
Durba Sengupta et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2015)
Can Specific Protein-Lipid Interactions Stabilize an Active State of the Beta 2 Adrenergic Receptor?
Chris Neale et al.
BIOPHYSICAL JOURNAL (2015)
Two disparate ligand-binding sites in the human P2Y1 receptor
Dandan Zhang et al.
NATURE (2015)
Structural insights into μ-opioid receptor activation
Weijiao Huang et al.
NATURE (2015)
Changes in Membrane Cholesterol Differentially Influence Preferential and Non-preferential Signaling of the M1 and M3 Muscarinic Acetylcholine Receptors
Pavel Michal et al.
NEUROCHEMICAL RESEARCH (2015)
The Molecular Basis of Oligomeric Organization of the Human M3 Muscarinic Acetylcholine Receptor
Maria Jose Varela Liste et al.
MOLECULAR PHARMACOLOGY (2015)
Stereospecific requirement of cholesterol in the function of the serotonin1A receptor
Md. Jafurulla et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2014)
Cholesterol Modulates the Dimer Interface of the β2-Adrenergic Receptor via Cholesterol Occupancy Sites
Xavier Prasanna et al.
BIOPHYSICAL JOURNAL (2014)
Two Classes of Cholesterol Binding Sites for the β2AR Revealed by Thermostability and NMR
Deborah L. Gater et al.
BIOPHYSICAL JOURNAL (2014)
Coupling of G Proteins to Reconstituted Monomers and Tetramers of the M2 Muscarinic Receptor
Dar'ya S. Redka et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Structure of the human P2Y12 receptor in complex with an antithrombotic drug
Kaihua Zhang et al.
NATURE (2014)
G Protein-Coupled Receptor Oligomerization Revisited: Functional and Pharmacological Perspectives
Sergi Ferre et al.
PHARMACOLOGICAL REVIEWS (2014)
The Dynamic Process of β2-Adrenergic Receptor Activation
Rie Nygaard et al.
CELL (2013)
Mapping the Functional Binding Sites of Cholesterol in β2-Adrenergic Receptor by Long-Time Molecular Dynamics Simulations
Xiaohui Cang et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2013)
GPCR activation: a mutagenic spotlight on crystal structures
Edward C. Hulme
TRENDS IN PHARMACOLOGICAL SCIENCES (2013)
How cholesterol interacts with membrane proteins: an exploration of cholesterol-binding sites including CRAC, CARC, and tilted domains
Jacques Fantini et al.
FRONTIERS IN PHYSIOLOGY (2013)
The Prevalence, Maintenance, and Relevance of G Protein-Coupled Receptor Oligomerization
Graeme Milligan
MOLECULAR PHARMACOLOGY (2013)
Action of Molecular Switches in GPCRs - Theoretical and Experimental Studies
B. Trzaskowski et al.
CURRENT MEDICINAL CHEMISTRY (2012)
Structure of the human κ-opioid receptor in complex with JDTic
Huixian Wu et al.
NATURE (2012)
Crystal structure of the μ-opioid receptor bound to a morphinan antagonist
Aashish Manglik et al.
NATURE (2012)
Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions
Wei Liu et al.
SCIENCE (2012)
Computational and Experimental Analysis of the Transmembrane Domain 4/5 Dimerization Interface of the Serotonin 5-HT1A Receptor
Nataliya Gorinski et al.
MOLECULAR PHARMACOLOGY (2012)
Identification of cholesterol recognition amino acid consensus (CRAC) motif in G-protein coupled receptors
Md. Jafurulla et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)
Cholesterol depletion enhances adrenergic signaling in cardiac myocytes
Yamuna Devi Paila et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2011)
Organization of Higher-Order Oligomers of the Serotonini1A Receptor Explored Utilizing Homo-FRET in Live Cells
Sourav Ganguly et al.
BIOPHYSICAL JOURNAL (2011)
Monomeric Rhodopsin Is Sufficient for Normal Rhodopsin Kinase (GRK1) Phosphorylation and Arrestin-1 Binding
Timothy H. Bayburt et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Structural Basis of M3 Muscarinic Receptor Dimer/Oligomer Formation
Sara M. McMillin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Oligomerization of the Serotonin1A Receptor in Live Cells: A Time-Resolved Fluorescence Anisotropy Approach
Yamuna Devi Paila et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2011)
Lipid rafts constrain basal α1A-adrenergic receptor signaling by maintaining receptor in an inactive conformation
Beilei Lei et al.
CELLULAR SIGNALLING (2009)
Membrane cholesterol content influences binding properties of muscarinic M2 receptors and differentially impacts activation of second messenger pathways
Pavel Michal et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2009)
Differential Effect of Membrane Cholesterol Removal on μ- and δ-Opioid Receptors A PARALLEL COMPARISON OF ACUTE AND CHRONIC SIGNALING TO ADENYLYL CYCLASE
Erica S. Levitt et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Purification and Functional Reconstitution of Monomeric μ-Opioid Receptors ALLOSTERIC MODULATION OF AGONIST BINDING BY Gi2
Adam J. Kuszak et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Membrane partitioning of various δ-opioid receptor forms before and after agonist activations:: The effect of cholesterol
Aurore Andre et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2008)
Lipid-mediated dimerization of β2-adrenergic receptor reveals important clues for cannabinoid receptors
E. Dainese et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2008)
Neuroactive steroid pregnenolone sulphate inhibits long-term potentiation via activation of α2-adrenoreceptors at excitatory synapses in rat medial prefrontal cortex
Ze-Min Wang et al.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY (2008)
Cholesterol-dependent Separation of the β2-Adrenergic Receptor from Its Partners Determines Signaling Efficacy INSIGHT INTO NANOSCALE ORGANIZATION OF SIGNAL TRANSDUCTION
Stephanie M. Pontier et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Binding of orthosteric ligands to the allosteric site of the M2 muscarinic cholinergic receptor
Dar'ya S. Redka et al.
MOLECULAR PHARMACOLOGY (2008)
A specific cholesterol binding site is established by the 2.8 Å structure of the human β2-adrenergic receptor
Michael A. Hanson et al.
STRUCTURE (2008)
Efficient coupling of transducin to monomeric rhodopsin in a phospholipid bilayer
Matthew R. Whorton et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
High-resolution crystal structure of an engineered human β2-adrenergic G protein-coupled receptor
Vadim Cherezov et al.
SCIENCE (2007)
Cholesterol as a determinant of cooperativity in the M2 muscarinic cholinergic receptor
Alejandro T. Colozo et al.
BIOCHEMICAL PHARMACOLOGY (2007)
Assessing the nature of lipid raft membranes
Perttu S. Niemela et al.
PLOS COMPUTATIONAL BIOLOGY (2007)
Dimerization of CXCR4 in living malignant cells: control of cell migration by a synthetic peptide that reduces homologous CXCR4 interactions
Jinhai Wang et al.
MOLECULAR CANCER THERAPEUTICS (2006)
Arrestin interaction with rhodopsin - Conceptual models
Anna Modzelewska et al.
CELL BIOCHEMISTRY AND BIOPHYSICS (2006)
Monitoring cholesterol organization in membranes at low concentrations utilizing the wavelength-selective fluorescence approach
S Mukherjee et al.
CHEMISTRY AND PHYSICS OF LIPIDS (2005)
Role of cholesterol in ligand binding and G-protein coupling of serotonin1A receptors solubilized from bovine hippocampus
A Chattopadhyay et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)
The G protein-coupled receptor rhodopsin in the native membrane
D Fotiadis et al.
FEBS LETTERS (2004)
A role for heterodimerization of μ and δ opiate receptors in enhancing morphine analgesia
I Gomes et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
The evolving role of lipid rafts and caveolae in G protein-coupled receptor signaling: implications for molecular pharmacology
RS Ostrom et al.
BRITISH JOURNAL OF PHARMACOLOGY (2004)
Oligomeric potential of the M2 muscarinic cholinergic receptor
PSH Park et al.
JOURNAL OF NEUROCHEMISTRY (2004)
Modulation of the firing activity of female dorsal raphe nucleus serotonergic neurons by neuroactive steroids
M Robichaud et al.
JOURNAL OF ENDOCRINOLOGY (2004)
Lipid-protein interactions in biological membranes: a structural perspective
AG Lee
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2003)
Ligand-independent dimerization of CXCR4, a principal HIV-1 coreceptor
GJ Babcock et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Cholesterol is essential for macrophage inflammatory protein 1β binding and conformational integrity of CC chemokine receptor 5
DH Nguyen et al.
BLOOD (2002)
Monitoring of ligand-independent dimerization and ligand-induced conformational changes of melatonin receptors in living cells by bioluminescence resonance energy transfer
MA Ayoub et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Cooperativity and oligomeric status of cardiac muscarinic cholinergic receptors
PSH Park et al.
BIOCHEMISTRY (2002)
Lipid rafts and signal transduction
K Simons et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2000)