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Efficacy and safety of fezakinumab (an IL-22 monoclonal antibody) in adults with moderate-to-severe atopic dermatitis inadequately controlled by conventional treatments: A randomized, double-blind, phase 2a trial
Emma Guttman-Yassky et al.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2018)
Alzheimer's disease research: the future of BACE inhibitors
Talha Burki
LANCET (2018)
The Role of Glucagon in the Pathophysiology and Treatment of Type 2 Diabetes
Sofie Haedersdal et al.
MAYO CLINIC PROCEEDINGS (2018)
Glucagon-like peptide 1 in health and disease
Andreas Andersen et al.
NATURE REVIEWS ENDOCRINOLOGY (2018)
Current Prophylactic Medications for Migraine and Their Potential Mechanisms of Action
Till Sprenger et al.
NEUROTHERAPEUTICS (2018)
A randomised double-blind placebo-controlled crossover trial of HUMira (adalimumab) for erosive hand OsteoaRthritis - the HUMOR trial
D. Aitken et al.
OSTEOARTHRITIS AND CARTILAGE (2018)
Peripherally administered calcitonin gene-related peptide induces spontaneous pain in mice: implications for migraine
Brandon J. Rea et al.
PAIN (2018)
A Mechanism-Based Approach to Physical Therapist Management of Pain
Ruth L. Chimenti et al.
PHYSICAL THERAPY (2018)
What is new in pain modification in osteoarthritis?
Rachel E. Miller et al.
RHEUMATOLOGY (2018)
Pancreas Transplantation at a Single Latin-American Center; Overall Results with Type 1 and Type 2 Diabetes Mellitus
G. E. Gondolesi et al.
TRANSPLANTATION PROCEEDINGS (2018)
Cromolyn Reduces Levels of the Alzheimer's Disease-Associated Amyloid β-Protein by Promoting Microglial Phagocytosis
Can Zhang et al.
SCIENTIFIC REPORTS (2018)
Brain Shuttle Antibody for Alzheimer's Disease with Attenuated Peripheral Effector Function due to an Inverted Binding Mode
Felix Weber et al.
CELL REPORTS (2018)
Cellular and Molecular Basis of Neurodegeneration in Parkinson Disease
Xian-Si Zeng et al.
FRONTIERS IN AGING NEUROSCIENCE (2018)
AAVrh.10-Mediated APOE2 Central Nervous System Gene Therapy for APOE4-Associated Alzheimer's Disease
Jonathan B. Rosenberg et al.
HUMAN GENE THERAPY CLINICAL DEVELOPMENT (2018)
A Multicenter, Double-Blind, Phase III Clinical Trial to Evaluate the Efficacy and Safety of a Cell and Gene Therapy in Knee Osteoarthritis Patients
Myung-Ku Kim et al.
HUMAN GENE THERAPY CLINICAL DEVELOPMENT (2018)
Brain Stimulation in Alzheimer's Disease
Chun-Hung Chang et al.
FRONTIERS IN PSYCHIATRY (2018)
Pharmacology of Recombinant Adeno-associated Virus Production
Magalie Penaud-Budloo et al.
MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT (2018)
The role of the JAK/STAT signal pathway in rheumatoid arthritis
Charles J. Malemud
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE (2018)
Clinical benefits of autologous haematopoietic stem cell transplantation in type 1 diabetes patients
B. Gu et al.
DIABETES & METABOLISM (2018)
MitoTALEN reduces mutant mtDNA load and restores tRNAAla levels in a mouse model of heteroplasmic mtDNA mutation
Sandra R. Bacman et al.
NATURE MEDICINE (2018)
Genome editing in mitochondria corrects a pathogenic mtDNA mutation in vivo
Payam A. Gammage et al.
NATURE MEDICINE (2018)
Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases
Claudio Soto et al.
NATURE NEUROSCIENCE (2018)
Propagation and spread of pathogenic protein assemblies in neurodegenerative diseases
Mathias Jucker et al.
NATURE NEUROSCIENCE (2018)
MECHANISMS OF INSULIN ACTION AND INSULIN RESISTANCE
Max C. Petersen et al.
PHYSIOLOGICAL REVIEWS (2018)
CGRP blockade by galcanezumab was not associated with reductions in signs and symptoms of knee osteoarthritis in a randomized clinical trial
Y. Jin et al.
OSTEOARTHRITIS AND CARTILAGE (2018)
The small molecule alpha-synuclein misfolding inhibitor, NPT200-11, produces multiple benefits in an animal model of Parkinson's disease
Diana L. Price et al.
SCIENTIFIC REPORTS (2018)
Prevalence of Chronic Pain and High-Impact Chronic Pain Among Adults - United States, 2016
James Dahlhamer et al.
MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2018)
Association of Pharmacological Treatments With Long-term Pain Control in Patients With Knee Osteoarthritis A Systematic Review and Meta-analysis
Dario Gregori et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2018)
New Frontiers in Parkinson's Disease: From Genetics to the Clinic
Lamya S. Shihabuddin et al.
JOURNAL OF NEUROSCIENCE (2018)
Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017
Spencer L. G. James et al.
LANCET (2018)
Efficacy and safety of LY3298176, a novel dual GIP and GLP-1 receptor agonist, in patients with type 2 diabetes: a randomised, placebo-controlled and active comparator-controlled phase 2 trial
Juan Pablo Frias et al.
LANCET (2018)
Lasmiditan is an effective acute treatment for migraine A phase 3 randomized study
Bernice Kuca et al.
NEUROLOGY (2018)
TREM2 in Alzheimer's Disease: Microglial Survival and Energy Metabolism
Honghua Zheng et al.
FRONTIERS IN AGING NEUROSCIENCE (2018)
Pharmacological Treatment of Pain in Osteoarthritis: A Descriptive Review
Muhammad Hassan Majeed et al.
CURRENT RHEUMATOLOGY REPORTS (2018)
Lasmiditan for the treatment of acute migraine: a review and potential role in clinical practice
Jessica C. Oswald et al.
JOURNAL OF PAIN RESEARCH (2018)
Knee osteoarthritis: pathophysiology and current treatment modalities
Juan C. Mora et al.
JOURNAL OF PAIN RESEARCH (2018)
LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: From discovery to clinical proof of concept
Tamer Coskun et al.
MOLECULAR METABOLISM (2018)
NEO6860, modality-selective TRPV1 antagonist: a randomized, controlled, proof-of-concept trial in patients with osteoarthritis knee pain
Pierre Arsenault et al.
PAIN REPORTS (2018)
Novel treatments for osteoarthritis: an update
Yong Wu et al.
OPEN ACCESS RHEUMATOLOGY-RESEARCH AND REVIEWS (2018)
12-month effects of incretins versus SGLT2-Inhibitors on cognitive performance and metabolic profile. A randomized clinical trial in the elderly with Type-2 diabetes mellitus
Simone Perna et al.
CLINICAL PHARMACOLOGY-ADVANCES AND APPLICATIONS (2018)
First-in-human topical microbiome transplantation with Roseomonas mucosa for atopic dermatitis
Ian A. Myles et al.
JCI INSIGHT (2018)
A PHASE 1, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, SINGLE- AND MULTIPLE-RISING DOSE STUDY OF THE BTK INHIBITOR TAK-020 IN HEALTHY VOLUNTEERS
E. Esfandiari et al.
ANNALS OF THE RHEUMATIC DISEASES (2018)
Development of Azeliragon, an Oral Small Molecule Antagonist of the Receptor for Advanced Glycation Endproducts, for the Potential Slowing of Loss of Cognition in Mild Alzheimer's Disease
A. H. Burstein et al.
JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE (2018)
A platform of genetically engineered bacteria as vehicles for localized delivery of therapeutics: Toward applications for Crohn's disease
Ryan McKay et al.
BIOENGINEERING & TRANSLATIONAL MEDICINE (2018)
Forecasting the care needs of the older population in England over the next 20 years: estimates from the Population Ageing and Care Simulation (PACSim) modelling study
Andrew Kingston et al.
LANCET PUBLIC HEALTH (2018)
Phase II evaluation of anti-MAdCAM antibody PF-00547659 in the treatment of Crohn's disease: report of the OPERA study
William J. Sandborn et al.
GUT (2018)
Risankizumab in patients with moderate to severe Crohn's disease: an open-label extension study
Brian G. Feagan et al.
LANCET GASTROENTEROLOGY & HEPATOLOGY (2018)
Alzheimer's disease: experimental models and reality
Eleanor Drummond et al.
ACTA NEUROPATHOLOGICA (2017)
Autologous tolerogenic dendritic cells for rheumatoid and inflammatory arthritis
G. M. Bell et al.
ANNALS OF THE RHEUMATIC DISEASES (2017)
Intravenous administration of expanded allogeneic adipose-derived mesenchymal stem cells in refractory rheumatoid arthritis (Cx611): results of a multicentre, dose escalation, randomised, single-blind, placebo-controlled phase Ib/Ila clinical trial
Jose M. Alvaro-Gracia et al.
ANNALS OF THE RHEUMATIC DISEASES (2017)
Natalizumab in the treatment of Crohn's disease patients
Cristiano Pagnini et al.
EXPERT OPINION ON BIOLOGICAL THERAPY (2017)
Serotonin receptor targeted therapy for migraine treatment: an overview of drugs in phase I and II clinical development
Piero Barbanti et al.
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2017)
Why do trials for Alzheimer's disease drugs keep failing? A discontinued drug perspective for 2010-2015
Dev Mehta et al.
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2017)
The potential of FimH as a novel therapeutic target for the treatment of Crohn's disease
Adeline Sivignon et al.
EXPERT OPINION ON THERAPEUTIC TARGETS (2017)
EB8018, A FIRST-IN-CLASS FIMH BLOCKER, REDUCES PRO-INFLAMMATORY CYTOKINES TNFI, IL6 AND IL8 IN SURGICAL EXPLANTS AND MAY REPRESENT A POTENTIAL NEW THERAPEUTIC APPROACH FOR THE TREATMENT OF CROHN'S DISEASE
Arnaud Laveissiere et al.
GASTROENTEROLOGY (2017)
The immunology of atopic dermatitis and its reversibility with broad-spectrum and targeted therapies
Patrick M. Brunner et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2017)
Effects of Regular and Long-Acting Insulin on Cognition and Alzheimer's Disease Biomarkers: A Pilot Clinical Trial
Suzanne Craft et al.
JOURNAL OF ALZHEIMERS DISEASE (2017)
Microglia in Alzheimer's disease
Heela Sarlus et al.
JOURNAL OF CLINICAL INVESTIGATION (2017)
Bacteriophages Targeting Adherent Invasive Escherichia coli Strains as a Promising New Treatment for Crohn's Disease
Matthieu Galtier et al.
JOURNAL OF CROHNS & COLITIS (2017)
Blocking CGRP in migraine patients - a review of pros and cons
Marie Deen et al.
JOURNAL OF HEADACHE AND PAIN (2017)
Therapeutic potential of mesenchymal stem cells for diabetes
Alvaro Moreira et al.
JOURNAL OF MOLECULAR ENDOCRINOLOGY (2017)
Pathogenetic insights from the treatment of rheumatoid arthritis
Iain B. McInnes et al.
LANCET (2017)
Solanezumab: too late in mild Alzheimer's disease?
[Anonymous]
LANCET NEUROLOGY (2017)
Crohn Disease: Epidemiology, Diagnosis, and Management
Joseph D. Feuerstein et al.
MAYO CLINIC PROCEEDINGS (2017)
Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug
Hao Wu et al.
NATURE MEDICINE (2017)
Breaking barriers to novel analgesic drug development
Ajay S. Yekkirala et al.
NATURE REVIEWS DRUG DISCOVERY (2017)
The emerging safety profile of JAK inhibitors in rheumatic disease
Kevin L. Winthrop
NATURE REVIEWS RHEUMATOLOGY (2017)
Immunogenicity and loss of response to TNF inhibitors: implications for rheumatoid arthritis treatment
Joachim R. Kalden et al.
NATURE REVIEWS RHEUMATOLOGY (2017)
Peripheral administration of the soluble TNF inhibitor XPro1595 modifies brain immune cell profiles, decreases beta-amyloid plaque load, and rescues impaired long-term potentiation in 5xFAD mice
Kathryn P. MacPherson et al.
NEUROBIOLOGY OF DISEASE (2017)
Synovial fluid pro-inflammatory profile differs according to the characteristics of knee pain
Y. Y. Leung et al.
OSTEOARTHRITIS AND CARTILAGE (2017)
Bruton's tyrosine kinase inhibitor BMS-986142 in experimental models of rheumatoid arthritis enhances efficacy of agents representing clinical standard-of-care
Kathleen M. Gillooly et al.
PLOS ONE (2017)
Single-cell transcriptomics to explore the immune system in health and disease
Michael J. T. Stubbington et al.
SCIENCE (2017)
Antimicrobials from human skin commensal bacteria protect against Staphylococcus aureus and are deficient in atopic dermatitis
Teruaki Nakatsuji et al.
SCIENCE TRANSLATIONAL MEDICINE (2017)
Efficacy of Autologous Bone Marrow-Derived Mesenchymal Stem Cell and Mononuclear Cell Transplantation in Type 2 Diabetes Mellitus: A Randomized, Placebo-Controlled Comparative Study
Shobhit Bhansali et al.
STEM CELLS AND DEVELOPMENT (2017)
TGF-β Family Signaling in Connective Tissue and Skeletal Diseases
Elena Gallo MacFarlane et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2017)
Spotlight on mavrilimumab for the treatment of rheumatoid arthritis: evidence to date
Chiara Crotti et al.
DRUG DESIGN DEVELOPMENT AND THERAPY (2017)
Platelet-Derived Mitochondria Display Embryonic Stem Cell Markers and Improve Pancreatic Islet β-cell Function in Humans
Yong Zhao et al.
STEM CELLS TRANSLATIONAL MEDICINE (2017)
Anti-Adhesion Therapies in inflammatory Bowel Disease-Molecular and Clinical Aspects
Sebastian Zundler et al.
FRONTIERS IN IMMUNOLOGY (2017)
Monomeric GLP-1/GIP/glucagon triagonism corrects obesity, hepatosteatosis, and dyslipidemia in female mice
Sigrid Jall et al.
MOLECULAR METABOLISM (2017)
T Cell-Mediated Beta Cell Destruction: Autoimmunity and Alloimmunity in the Context of Type 1 Diabetes
Adam L. Burrack et al.
FRONTIERS IN ENDOCRINOLOGY (2017)
Current understanding of the molecular mechanisms in Parkinson's disease: Targets for potential treatments
Panchanan Maiti et al.
TRANSLATIONAL NEURODEGENERATION (2017)
The role of anti-citrullinated protein antibodies (ACPA) in the pathogenesis of rheumatoid arthritis
Weronika Kurowska et al.
CENTRAL EUROPEAN JOURNAL OF IMMUNOLOGY (2017)
Next-generation anti-CD20 monoclonal antibodies in autoimmune disease treatment
Fanny Huynh Du et al.
AUTOIMMUNITY HIGHLIGHTS (2017)
Canagliflozin: A Review in Type 2 Diabetes
Emma D. Deeks et al.
DRUGS (2017)
APP mouse models for Alzheimer's disease preclinical studies
Hiroki Sasaguri et al.
EMBO JOURNAL (2017)
Subthalamic Nucleus Deep Brain Stimulation: Basic Concepts and Novel Perspectives
Clement Hamani et al.
ENEURO (2017)
New Modalities for Challenging Targets in Drug Discovery
Eric Valeur et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)
Autoimmune diseases and their relation with immunological, neurological and endocrinological axes
Nicolas Coronel-Restrepo et al.
AUTOIMMUNITY REVIEWS (2017)
Abatacept: A Review in Rheumatoid Arthritis
Hannah A. Blair et al.
DRUGS (2017)
The multiple pathways to autoimmunity
Argyrios N. Theofilopoulos et al.
NATURE IMMUNOLOGY (2017)
Current and emerging concepts in atopic dermatitis pathogenesis
Marguerite Sullivan et al.
CLINICS IN DERMATOLOGY (2017)
Modulation of sphingosine-1-phosphate in inflammatory bowel disease
Laurent Peyrin-Biroulet et al.
AUTOIMMUNITY REVIEWS (2017)
Is Alzheimer's disease a Type 3 Diabetes? A critical appraisal
Ramesh Kandimalla et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2017)
Saxagliptin/Dapagliflozin: A Review in Type 2 Diabetes Mellitus
Karly P. Garnock-Jones
DRUGS (2017)
Sitagliptin: A Review in Type 2 Diabetes
Lesley J. Scott
DRUGS (2017)
Type 1 Diabetes-A Clinical Perspective
Lindy Kahanovitz et al.
POINT OF CARE (2017)
Global vision of druggability issues: applications and perspectives
Hiba Abi Hussein et al.
DRUG DISCOVERY TODAY (2017)
Nerve growth factor blockade for the management of osteoarthritis pain: what can we learn from clinical trials and preclinical models?
Rachel E. Miller et al.
CURRENT OPINION IN RHEUMATOLOGY (2017)
Immunoablation and autologous hematopoietic stem cell transplantation in the treatment of new-onset type 1 diabetes mellitus: long-term observations
E. Snarski et al.
BONE MARROW TRANSPLANTATION (2016)
Role of RAGE in Alzheimer's Disease
Zhiyou Cai et al.
CELLULAR AND MOLECULAR NEUROBIOLOGY (2016)
A-to-I editing of coding and non-coding RNAs by ADARs
Kazuko Nishikura
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2016)
VX-509 (Decernotinib), an Oral Selective JAK-3 Inhibitor, in Combination With Methotrexate in Patients With Rheumatoid Arthritis
Mark C. Genovese et al.
ARTHRITIS & RHEUMATOLOGY (2016)
Current status of selected oral peptide technologies in advanced preclinical development and in clinical trials
T. A. S. Aguirre et al.
ADVANCED DRUG DELIVERY REVIEWS (2016)
Performance and complications of lumbar puncture in memory clinics: Results of the multicenter lumbar puncture feasibility study
Flora H. Duits et al.
ALZHEIMERS & DEMENTIA (2016)
Why has therapy development for dementia failed in the last two decades?
Serge Gauthier et al.
ALZHEIMERS & DEMENTIA (2016)
Neuroinflammation in Alzheimer's disease: Current evidence and future directions
Valeria Calsolaro et al.
ALZHEIMERS & DEMENTIA (2016)
Recent Progress in JAK Inhibitors for the Treatment of Rheumatoid Arthritis
Shingo Nakayamada et al.
BIODRUGS (2016)
Pancreas transplantation: a decade of decline
Robert J. Stratta et al.
CURRENT OPINION IN ORGAN TRANSPLANTATION (2016)
The Pharmacological Therapy of Chronic Neuropathic Pain
Andreas Binder et al.
DEUTSCHES ARZTEBLATT INTERNATIONAL (2016)
Incretin therapies: highlighting common features and differences in the modes of action of glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors
M. Nauck
DIABETES OBESITY & METABOLISM (2016)
THE ROLE OF GLUCAGON IN THE PATHOPHYSIOLOGY AND MANAGEMENT OF DIABETES
Georgia R. Kulina et al.
ENDOCRINE PRACTICE (2016)
Re-engineering therapeutic antibodies for Alzheimer's disease as blood-brain barrier penetrating bi-specific antibodies
William M. Pardridge
EXPERT OPINION ON BIOLOGICAL THERAPY (2016)
Investigational Bruton's tyrosine kinase inhibitors for the treatment of rheumatoid arthritis
Peter Norman
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2016)
Targeting the T Helper 2 Inflammatory Axis in Atopic Dermatitis
Adriana S. Moreno et al.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY (2016)
Metformin in Amnestic Mild Cognitive Impairment: Results of a Pilot Randomized Placebo Controlled Clinical Trial
Jose A. Luchsinger et al.
JOURNAL OF ALZHEIMERS DISEASE (2016)
Activation of β-Glucocerebrosidase Reduces Pathological α-Synuclein and Restores Lysosomal Function in Parkinson's Patient Midbrain Neurons
Joseph R. Mazzulli et al.
JOURNAL OF NEUROSCIENCE (2016)
Efficacy and safety of tau-aggregation inhibitor therapy in patients with mild or moderate Alzheimer's disease: a randomised, controlled, double-blind, parallel-arm, phase 3 trial
Serge Gauthier et al.
LANCET (2016)
Peptide- and Amine-Modified Glucan Particles for the Delivery of Therapeutic siRNA
Jessica L. Cohen et al.
MOLECULAR PHARMACEUTICS (2016)
Targeted Delivery of an Anti-inflammatory PDE4 Inhibitor to Immune Cells via an Antibody-drug Conjugate
Shan Yu et al.
MOLECULAR THERAPY (2016)
Development of an Innovative Intradermal siRNA Delivery System Using a Combination of a Functional Stearylated Cytoplasm-Responsive Peptide and a Tight Junction-Opening Peptide
Hisako Ibaraki et al.
MOLECULES (2016)
Inhibiting tumor necrosis factor-α before amyloidosis prevent synaptic deficits in an Alzheimer's disease model
Chelsea Cavanagh et al.
NEUROBIOLOGY OF AGING (2016)
Antibiotics in Early Life Alter the Gut Microbiome and Increase Disease Incidence in a Spontaneous Mouse Model of Autoimmune Insulin-Dependent Diabetes (vol 10, e0125448, 2015)
Sophie Candon et al.
PLOS ONE (2016)
Bapineuzumab for mild to moderate Alzheimer's disease in two global, randomized, phase 3 trials
Rik Vandenberghe et al.
ALZHEIMERS RESEARCH & THERAPY (2016)
Suppression of Inflammatory Arthritis by Human Gut-Derived Prevotella histicola in Humanized Mice
Eric V. Marietta et al.
Arthritis & Rheumatology (2016)
Anti-nerve growth factor in pain management: current evidence
David S. Chang et al.
JOURNAL OF PAIN RESEARCH (2016)
Dendritic Cell-based Immunotherapy for Rheumatoid Arthritis: from Bench to Bedside
Md. Selim Ahmed et al.
IMMUNE NETWORK (2016)
Tanezumab for Patients with Osteoarthritis of the Knee: A Meta-Analysis
Shun-Li Kan et al.
PLOS ONE (2016)
Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer's disease
Myles R. Minter et al.
SCIENTIFIC REPORTS (2016)
Islet-like organoids derived from human pluripotent stem cells efficiently function in the glucose responsiveness in vitro and in vivo
Youngjin Kim et al.
SCIENTIFIC REPORTS (2016)
Molecular Insight into Gut Microbiota and Rheumatoid Arthritis
Xiaohao Wu et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)
Molecular Mechanisms of Cutaneous Inflammatory Disorder: Atopic Dermatitis
Jung Eun Kim et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)
ACPAs Are Much More Than Diagnostic Autoantibodies
Abdulla Watad et al.
RAMBAM MAIMONIDES MEDICAL JOURNAL (2016)
Transplantation of human skin microbiota in models of atopic dermatitis
Ian A. Myles et al.
JCI INSIGHT (2016)
Atopic Dermatitis: Global Epidemiology and Risk Factors
Sophie Nutten
ANNALS OF NUTRITION AND METABOLISM (2015)
Insulin-secreting adipose-derived mesenchymal stromal cells with bone marrow-derived hematopoietic stem cells from autologous and allogenic sources for type 1 diabetes mellitus
Umang G. Thakkar et al.
CYTOTHERAPY (2015)
Allogeneic Mesenchymal Precursor Cells in Type 2 Diabetes: A Randomized, Placebo-Controlled, Dose-Escalation Safety and Tolerability Pilot Study
Jay S. Skyler et al.
DIABETES CARE (2015)
Alogliptin: A Review of Its Use in Patients with Type 2 Diabetes Mellitus
Gillian M. Keating
DRUGS (2015)
Masitinib for the treatment of mild to moderate Alzheimer's disease
Jaume Folch et al.
EXPERT REVIEW OF NEUROTHERAPEUTICS (2015)
Genetics of autoimmune diseases: insights from population genetics
Paula S. Ramos et al.
JOURNAL OF HUMAN GENETICS (2015)
Neuroinflammation in Alzheimer's disease
Michael T. Heneka et al.
LANCET NEUROLOGY (2015)
Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota
Kristoffer Forslund et al.
NATURE (2015)
The role of gut microbiota in the development of type 1, type 2 diabetes mellitus and obesity
Ningwen Tai et al.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS (2015)
Alzheimer's and Parkinson's diseases: The prion concept in relation to assembled Aβ, tau, and α-synuclein
Michel Goedert
SCIENCE (2015)
Autocrine selection of a GLP-1R G-protein biased agonist with potent antidiabetic effects
Hongkai Zhang et al.
NATURE COMMUNICATIONS (2015)
Masitinib for the treatment of mild to moderate Alzheimer's disease
Jaume Folch et al.
EXPERT REVIEW OF NEUROTHERAPEUTICS (2015)
Modulation of Autoimmune T-Cell Memory by Stem Cell Educator Therapy: Phase 1/2 Clinical Trial
Elias Delgado et al.
EBIOMEDICINE (2015)
Adalimumab in patients with hand osteoarthritis refractory to analgesics and NSAIDs: a randomised, multicentre, double- blind, placebo-controlled trial
X. Chevalier et al.
ANNALS OF THE RHEUMATIC DISEASES (2015)
Efficacy and safety of tanezumab monotherapy or combined with non-steroidal anti-inflammatory drugs in the treatment of knee or hip osteoarthritis pain
Thomas J. Schnitzer et al.
ANNALS OF THE RHEUMATIC DISEASES (2015)
Progress toward the development of in vitro model system for chemical-induced developmental neurotoxicity: potential applicability of stem cells
V. Kumar et al.
ARCHIVES OF TOXICOLOGY (2015)
Targeted Delivery of Protein and Gene Medicines Through the Blood-Brain Barrier
W. M. Pardridge
CLINICAL PHARMACOLOGY & THERAPEUTICS (2015)
Preserved β-Cell Function in Type 1 Diabetes by Mesenchymal Stromal Cells
Per-Ola Carlsson et al.
DIABETES (2015)
A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents
Brian Finan et al.
NATURE MEDICINE (2015)
Antibiotics in Early Life Alter the Gut Microbiome and Increase Disease Incidence in a Spontaneous Mouse Model of Autoimmune Insulin-Dependent Diabetes
Sophie Candon et al.
PLOS ONE (2015)
Novel therapy for insulin-dependent diabetes mellitus: infusion of in vitro-generated insulin-secreting cells
S. D. Dave et al.
CLINICAL AND EXPERIMENTAL MEDICINE (2015)
Long-Acting Intranasal Insulin Detemir Improves Cognition for Adults with Mild Cognitive Impairment or Early-Stage Alzheimer's Disease Dementia
Amy Claxton et al.
JOURNAL OF ALZHEIMERS DISEASE (2015)
The oligomer modulator anle138b inhibits disease progression in a Parkinson mouse model even with treatment started after disease onset
Johannes Levin et al.
ACTA NEUROPATHOLOGICA (2014)
A phase1 study of stereotactic gene delivery of AAV2-NGF for Alzheimer's disease
Michael S. Rafii et al.
ALZHEIMERS & DEMENTIA (2014)
SAT0117 Sarilumab, a Subcutaneously-Administered, Fully-Human Monoclonal Antibody Inhibitor of The IL-6 Receptor: Relationship Between Eular Responses and Change from Baseline of Selected Clinical Parameters
M. C. Genovese et al.
ANNALS OF THE RHEUMATIC DISEASES (2014)
AB0037 Evaluation of the binding kinetics and functional bioassay activity of sarilumab and tocilizumab to the human il-6 receptor (il-6r) alpha
A. Rafique et al.
ANNALS OF THE RHEUMATIC DISEASES (2014)
Autologous Nonmyeloablative Hematopoietic Stem Cell Transplantation in New-Onset Type 1 Diabetes: A Multicenter Analysis
Francesca D'Addio et al.
DIABETES (2014)
Low-Dose Otelixizumab Anti-CD3 Monoclonal Antibody DEFEND-1 Study: Results of the Randomized Phase III Study in Recent-Onset Human Type 1 Diabetes
Ronnie Aronson et al.
DIABETES CARE (2014)
GAD-treatment of children and adolescents with recent-onset type 1 diabetes preserves residual insulin secretion after 30 months
Johnny Ludvigsson et al.
DIABETES-METABOLISM RESEARCH AND REVIEWS (2014)
Efficacy and safety of low-dose otelixizumab anti-CD3 monoclonal antibody in preserving C-peptide secretion in adolescent type 1 diabetes: DEFEND-2, a randomized, placebo-controlled, double-blind, multi-centre study
P. Ambery et al.
DIABETIC MEDICINE (2014)
Aberrant gut microbiota composition at the onset of type 1 diabetes in young children
Marcus C. de Goffau et al.
DIABETOLOGIA (2014)
Bruton's tyrosine kinase inhibitors for the treatment of rheumatoid arthritis
Jennifer A. Whang et al.
DRUG DISCOVERY TODAY (2014)
Noninvasive delivery of siRNA and plasmid DNA into skin by fractional ablation: Erbium:YAG laser versus CO2 laser
Woan-Ruoh Lee et al.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2014)
Pharmacological Treatment of Parkinson Disease A Review
Barbara S. Connolly et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2014)
Insulin Therapy for Type 2 Diabetes Mellitus
Amisha Wallia et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2014)
Metformin in Patients With Type 2 Diabetes and Kidney Disease A Systematic Review
Silvio E. Inzucchi et al.
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2013)
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FEBS JOURNAL (2013)
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HUMAN MOLECULAR GENETICS (2013)
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BIOCHEMICAL JOURNAL (2012)
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BMC MEDICINE (2012)
Stem Cell Educator Therapy and Induction of Immune Balance
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Linagliptin A Review of its Use in the Management of Type 2 Diabetes Mellitus
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JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2012)
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NATURE CHEMICAL BIOLOGY (2012)
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John C. Pickup
NEW ENGLAND JOURNAL OF MEDICINE (2012)
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PLOS ONE (2012)
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POSTGRADUATE MEDICINE (2012)
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INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (2012)
Linagliptin for type 2 diabetes mellitus: a review of the pivotal clinical trials
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ANNALS OF NEUROLOGY (2011)
Interactions Between Gut Microbiota and Host Metabolism Predisposing to Obesity and Diabetes
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ANNUAL REVIEW OF MEDICINE, VOL 62, 2011 (2011)
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BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2011)
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Current Neuropharmacology (2011)
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CURRENT TREATMENT OPTIONS IN NEUROLOGY (2011)
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LANCET (2011)
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LANCET (2011)
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NEW ENGLAND JOURNAL OF MEDICINE (2011)
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Masitinib as an adjunct therapy for mild-to-moderate Alzheimer's disease: a randomised, placebo-controlled phase 2 trial
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ALZHEIMERS RESEARCH & THERAPY (2011)
Transplantation of placenta-derived mesenchymal stem cells in type 2 diabetes: a pilot study
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Frontiers of Medicine (2011)
Mechanism of action of cholinesterase inhibitors in Alzheimer's disease
L. Håkansson
ACTA NEUROLOGICA SCANDINAVICA (2010)
The synaptic pathology of α-synuclein aggregation in dementia with Lewy bodies, Parkinson's disease and Parkinson's disease dementia
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ACTA NEUROPATHOLOGICA (2010)
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AMERICAN JOURNAL OF TRANSPLANTATION (2010)
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AMERICAN JOURNAL OF TRANSPLANTATION (2010)
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Annabelle R. Charbit et al.
CURRENT OPINION IN NEUROLOGY (2010)
Impact of pancreas transplantation on type 1 diabetes-related complications
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CURRENT OPINION IN ORGAN TRANSPLANTATION (2010)
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IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA (2010)
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INFLAMMATORY BOWEL DISEASES (2010)
Neuropathologic Alterations in Mild Cognitive Impairment: A Review
William R. Markesbery
JOURNAL OF ALZHEIMERS DISEASE (2010)
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JOURNAL OF CHEMICAL EDUCATION (2010)
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LANCET NEUROLOGY (2010)
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Jeffrey A. Bluestone et al.
NATURE (2010)
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Lucienne Chatenoud
NATURE REVIEWS ENDOCRINOLOGY (2010)
Insulin-Heparin Infusions Peritransplant Substantially Improve Single-Donor Clinical Islet Transplant Success
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TRANSPLANTATION (2010)
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JOURNAL OF DIABETES INVESTIGATION (2010)
Update on the use of memantine in Alzheimer’s disease
Rob Marum
Neuropsychiatric Disease and Treatment (2010)
Cotransplantation of Adipose Tissue-Derived Insulin-Secreting Mesenchymal Stem Cells and Hematopoietic Stem Cells: A Novel Therapy for Insulin-Dependent Diabetes Mellitus
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STEM CELLS INTERNATIONAL (2010)
Proinsulin peptide immunotherapy in type 1 diabetes: report of a first-in-man Phase I safety study
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CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2009)
Treatment of patients with new onset Type 1 diabetes with a single course of anti-CD3 mAb teplizumab preserves insulin production for up to 5 years
Kevan C. Herold et al.
CLINICAL IMMUNOLOGY (2009)
Discussion: DMARDs and biologic therapies in the management of inflammatory joint diseases
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EXPERT REVIEW OF CLINICAL IMMUNOLOGY (2009)
mTORC1 Activation Regulates β-Cell Mass and Proliferation by Modulation of Cyclin D2 Synthesis and Stability
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JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Origin of pain in migraine: evidence for peripheral sensitisation
Jes Olesen et al.
LANCET NEUROLOGY (2009)
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NATURE REVIEWS DRUG DISCOVERY (2009)
Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology
Fiona E. McAlpine et al.
NEUROBIOLOGY OF DISEASE (2009)
Rituximab, B-Lymphocyte Depletion, and Preservation of Beta-Cell Function
Mark D. Pescovitz et al.
NEW ENGLAND JOURNAL OF MEDICINE (2009)
Human Cord Blood Stem Cell-Modulated Regulatory T Lymphocytes Reverse the Autoimmune-Caused Type 1 Diabetes in Nonobese Diabetic (NOD) Mice
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PLOS ONE (2009)
Review: Deep brain stimulation in Parkinson’s disease
S.J. Groiss et al.
Therapeutic Advances in Neurological Disorders (2009)
Anti-adhesion molecule strategies for Crohn disease
Yvette Leung et al.
BIODRUGS (2008)
A review of Parkinson's disease
C. A. Davie
BRITISH MEDICAL BULLETIN (2008)
A pilot study of the effects of pioglitazone and rosiglitazone on de novo lipogenesis in type 2 diabetes
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JOURNAL OF LIPID RESEARCH (2008)
High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice
L. Thirumangalakudi et al.
JOURNAL OF NEUROCHEMISTRY (2008)
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N. Ahmad Aziz et al.
JOURNAL OF NEUROLOGY (2008)
Innate immunity and intestinal microbiota in the development of Type 1 diabetes
Li Wen et al.
NATURE (2008)
Protective effects of NSAIDs on the development of Alzheimer disease
Steven C. Vlad et al.
NEUROLOGY (2008)
GAD treatment and insulin secretion in recent-onset type 1 diabetes
Johnny Ludvigsson et al.
NEW ENGLAND JOURNAL OF MEDICINE (2008)
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George Razay et al.
Expert Review of Neurotherapeutics (2007)
B lymphocyte - directed immunotherapy promotes long-term islet allograft survival in nonhuman primates
Chengyang Liu et al.
NATURE MEDICINE (2007)
Dopamine and migraine: biology and clinical implications
S. Akerman et al.
CEPHALALGIA (2007)
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S. Edwin Fineberg et al.
ENDOCRINE REVIEWS (2007)
Heat-shock protein peptide DiaPep277 treatment in children with newly diagnosed type 1 diabetes: a randomised, double-blind phase II study
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DIABETES-METABOLISM RESEARCH AND REVIEWS (2007)
Autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus
Julio C. Voltarelli et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2007)
TSLP: An epithelial cell cytokine that regulates T cell differentiation by conditioning dendritic cell maturation
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ANNUAL REVIEW OF IMMUNOLOGY (2007)
Rivastigmine in the treatment of Alzheimer's disease: an update
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CLINICAL INTERVENTIONS IN AGING (2007)
Arthritis and pain - Future targets to control osteoarthritis pain
Andy Dray et al.
ARTHRITIS RESEARCH & THERAPY (2007)
Mechanisms linking obesity to insulin resistance and type 2 diabetes
Steven E. Kahn et al.
NATURE (2006)
International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors
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PHARMACOLOGICAL REVIEWS (2006)
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NEW ENGLAND JOURNAL OF MEDICINE (2006)
Pancreatic signals controlling food intake; insulin, glucagon and amylin
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PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2006)
IL-31: A new link between T cells and pruritus in atopic skin inflammation
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JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2006)
Mechanism of action of memantine
JW Johnson et al.
CURRENT OPINION IN PHARMACOLOGY (2006)
Pramlintide in the treatment of type 1 and type 2 diabetes mellitus
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CLINICAL THERAPEUTICS (2005)
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CURRENT MEDICAL RESEARCH AND OPINION (2005)
Osteoarthritis: An overview of the disease and its treatment strategies
P Sarzi-Puttini et al.
SEMINARS IN ARTHRITIS AND RHEUMATISM (2005)
Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes
B Keymeulen et al.
NEW ENGLAND JOURNAL OF MEDICINE (2005)
Hematopoietic stem cell transplantation prevents diabetes in NOD mice but does not contribute to significant islet cell regeneration once disease is established
EM Kang et al.
EXPERIMENTAL HEMATOLOGY (2005)
Parenteral dihydroergotamine for acute migraine headache: A systematic review of the literature
I Colman et al.
ANNALS OF EMERGENCY MEDICINE (2005)
Amantadine inhibits NMDA receptors by accelerating channel closure during channel block
TA Blanpied et al.
JOURNAL OF NEUROSCIENCE (2005)
Single-donor, marginal-dose islet transplantation in patients with type 1 diabetes
BJ Hering et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2005)
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CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2005)
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S Papapetropoulos et al.
EUROPEAN JOURNAL OF NEUROLOGY (2004)
Amyloid β peptide load is correlated with increased β-secretase activity in sporadic Alzheimer's disease patients
R Li et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Specific autoantibodies precede the symptoms of rheumatoid arthritis - A study of serial measurements in blood donors
MMJ Nielen et al.
ARTHRITIS AND RHEUMATISM (2004)
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GENE THERAPY (2004)
Long term motor complications of levodopa: clinical features, mechanisms, and management strategies
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POSTGRADUATE MEDICAL JOURNAL (2004)
O-GlcNAcylation regulates phosphorylation of tau: A mechanism involved in Alzheimer's disease
F Liu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Protein aggregation and neurodegenerative disease
CA Ross et al.
NATURE MEDICINE (2004)
Amylin replacement with pramlintide as an adjunct to insulin therapy improves long-term glycaemic and weight control in Type 1 diabetes mellitus: a 1-year, randomized controlled trial
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DIABETIC MEDICINE (2004)
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SCIENCE (2003)
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A long-term comparison of galantamine and donepezil in the treatment of Alzheimer's disease
G Wilcock et al.
DRUGS & AGING (2003)
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C Soto
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Dopamine agonist monotherapy in Parkinson's disease
CE Clarke et al.
LANCET (2002)
β-secretase protein and activity are increased in the neocortex in Alzheimer disease
H Fukumoto et al.
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JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Metformin: An update
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ANNALS OF INTERNAL MEDICINE (2002)
Acarbose for prevention of type 2 diabetes mellitus: the STOPNIDDM randomised trial
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LANCET (2002)
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EUROPEAN JOURNAL OF ENDOCRINOLOGY (2002)
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NEW ENGLAND JOURNAL OF MEDICINE (2002)
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G Gold et al.
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A review of rosiglitazone in type 2 diabetes mellitus
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High-frequency stimulation produces a transient blockade of voltage-gated currents in subthalamic neurons
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M Goedert
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Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen.
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NEW ENGLAND JOURNAL OF MEDICINE (2000)
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GUT (2000)
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S Kaakkola
DRUGS (2000)
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INTERNIST (2000)
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DRUGS (2000)
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