期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 22, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/ijms22052542
关键词
cancer thersapy; hyperthermia; MNPs; DOX; HSPs inhibitor; nanofiber
资金
- JSPS KAKENHI [JP19H04476, JP20H05877]
This study demonstrates the rational fabrication of a magnetic composite nanofiber mesh that exhibits distinct hyperthermia, enhanced chemotherapeutic efficiency, and thermo-molecularly targeted therapy for potent therapeutic effects in cancer treatment. The nanofiber system represents a smart approach for localized medication delivery and may offer a new strategy for advanced cancer therapy.
This study demonstrates the rational fabrication of a magnetic composite nanofiber mesh that can achieve mutual synergy of hyperthermia, chemotherapy, and thermo-molecularly targeted therapy for highly potent therapeutic effects. The nanofiber is composed of biodegradable poly(epsilon-caprolactone) with doxorubicin, magnetic nanoparticles, and 17-allylamino-17-demethoxygeldanamycin. The nanofiber exhibits distinct hyperthermia, owing to the presence of magnetic nanoparticles upon exposure of the mesh to an alternating magnetic field, which causes heat-induced cell killing as well as enhanced chemotherapeutic efficiency of doxorubicin. The effectiveness of hyperthermia is further enhanced through the inhibition of heat shock protein activity after hyperthermia by releasing the inhibitor 17-allylamino-17-demethoxygeldanamycin. These findings represent a smart nanofiber system for potent cancer therapy and may provide a new approach for the development of localized medication delivery.
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