期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 22, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/ijms22052454
关键词
cannabinoid biosynthesis; metabolic engineering; synthetic biology; yeast fermentation; polyketide synthase; aromatic prenyltransferase; FAD-dependent monooxygenase
资金
- NSERC Alexander Graham Bell Canada Graduate Scholarship
- Cannabis Health Research Chair grant (New Brunswick Health Research Foundation/Tetra Bio Pharma Inc.)
- New Brunswick Innovation Foundation [REP_2019_007]
The rapid growth of the global cannabis economy is driven by the medicinal properties of cannabis and its legal status in multiple countries. Besides THC, non-psychoactive phytocannabinoids are also rapidly developing and have the potential to become clinically useful drugs.
The medicinal properties of cannabis and the its legal status in several countries and jurisdictions has spurred the massive growth of the cannabis economy around the globe. The value of cannabis stems from its euphoric activity offered by the unique phytocannabinoid tetrahydrocannabinol (THC). However, this is rapidly expanding beyond THC owing to other non-psychoactive phytocannabinoids with new bioactivities that will contribute to their development into clinically useful drugs. The discovery of the biosynthesis of major phytocannabinoids has allowed the exploration of their heterologous production by synthetic biology, which may lead to the industrial production of rare phytocannabinoids or novel synthetic cannabinoid pharmaceuticals that are not easily offered by cannabis plants. This review summarizes the biosynthesis of major phytocannabinoids in detail, the most recent development of their metabolic engineering in various systems, and the engineering approaches and strategies used to increase the yield.
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