期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 22, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/ijms22042067
关键词
metastatic colorectal cancer; targeted therapy; immunotherapy; tumour microenvironment; inflammation; cytokines; tumour heterogeneity
资金
- Cancer Council Victoria [1143036]
- Austin Medical Research Fund
- La Trobe RFA Scheme
- Victorian Cancer Agency [19014]
- Victorian State Government Operational Infrastructure Support Scheme
- ONJCRI
- La Trobe University Full-Fee Research Scholarship
- La Trobe University Postgraduate Research Scholarship
Liver metastasis is a significant factor in the mortality of colorectal cancer patients. Understanding the cellular interactions in the tumor microenvironment can lead to the development of new therapeutic targets for metastatic colorectal cancer, despite current treatment challenges.
Liver metastasis is the primary contributor to the death of patients with colorectal cancer. Despite the overall success of current treatments including targeted therapy, chemotherapy, and immunotherapy combinations in colorectal cancer patients, the prognosis of patients with liver metastasis remains poor. Recent studies have highlighted the importance of the tumour microenvironment and the crosstalk within that determines the fate of circulating tumour cells in distant organs. Understanding the interactions between liver resident cells and tumour cells colonising the liver opens new therapeutic windows for the successful treatment of metastatic colorectal cancer. Here we discuss critical cellular interactions within the tumour microenvironment in primary tumours and in liver metastases that highlight potential therapeutic targets. We also discuss recent therapeutic advances for the treatment of metastatic colorectal cancer.
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