期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 22, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/ijms22052619
关键词
osteoarthritis; diagnosis; management; surgery; cell therapy; embryonic stem cells; induced pluripotent stem cells; mesenchymal stem cells
资金
- Korea Healthcare Technology R&D project, Ministry for Health, Welfare & Family Affairs, Republic of Korea [HI20C0495]
- National Research Foundation of Korea (NRF) - Korean government (MSIT) [2020R1A2C3004123]
- Korea Health Promotion Institute [HI20C0495000021] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2020R1A2C3004123] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Osteoarthritis (OA) is a degenerative and chronic joint disease that primarily damages joint cartilage, causing pain, swelling, and stiffness. With the aging population and increasing prevalence of obesity, the prevalence of OA is expected to rise. Recent advances in understanding the mechanisms, diagnosis, and management of OA have led to many potential therapeutic advances.
Osteoarthritis (OA) is a degenerative and chronic joint disease characterized by clinical symptoms and distortion of joint tissues. It primarily damages joint cartilage, causing pain, swelling, and stiffness around the joint. It is the major cause of disability and pain. The prevalence of OA is expected to increase gradually with the aging population and increasing prevalence of obesity. Many potential therapeutic advances have been made in recent years due to the improved understanding of the underlying mechanisms, diagnosis, and management of OA. Embryonic stem cells and induced pluripotent stem cells differentiate into chondrocytes or mesenchymal stem cells (MSCs) and can be used as a source of injectable treatments in the OA joint cavity. MSCs are known to be the most studied cell therapy products in cell-based OA therapy owing to their ability to differentiate into chondrocytes and their immunomodulatory properties. They have the potential to improve cartilage recovery and ultimately restore healthy joints. However, despite currently available therapies and advances in research, unfulfilled medical needs persist for OA treatment. In this review, we focused on the contents of non-cellular and cellular therapies for OA, and briefly summarized the results of clinical trials for cell-based OA therapy to lay a solid application basis for clinical research.
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