4.6 Article

Upregulated miR-411-5p levels promote lymph node metastasis by targeting RYBP in head and neck squamous cell carcinoma

期刊

出版社

SPANDIDOS PUBL LTD
DOI: 10.3892/ijmm.2021.4869

关键词

head and neck squamous cell carcinoma; metastasis; epithelial mesenchymal transition; microRNA-411-5p; RING1 and YY1 binding protein

资金

  1. National Nature Science Foundation of China [81870769]
  2. Guangdong Financial Fund for High-Caliber Hospital Construction [174-2018-XMZC-0001-03-0125/D-05]

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miR-411-5p plays a crucial role in promoting metastasis in HNSCC by downregulating RYBP expression levels, indicating it as a potential novel target for HNSCC treatment.
Metastasis is the primary cause of the high mortality rates in head and neck squamous cell carcinoma (HNSCC). MicroRNA (miR)-411-5p has been discovered to serve an important role in cancer metastases. However, to the best of our knowledge, the association between miR-411-5p expression levels and HNSCC metastasis has not been thoroughly investigated. The present study aimed to research the function of miR-411-5p in HNSCC metastasis. The results of the present study revealed that miR-411-5p expression levels were upregulated in patients with HNSCC with lymph node metastasis and the upregulated expression levels of miR-411-5p were positively associated with the metastatic potential of HNSCC. Moreover, miR-411-5p promoted HNSCC cell migration, invasion and epithelial-mesenchymal transition (EMT). The results of the dual-luciferase reporter assays identified RING1 and YY1 binding protein (RYBP) as a functional downstream target gene for miR-411-5p. Therefore, whether miR-411-5p downregulated the expression levels of RYBP in HNSCC cells was subsequently investigated. Notably, the silencing of RYBP expression restored the stimulatory effects of miR-411-5p on HNSCC cell migration, invasion and EMT. In addition, the mRNA expression levels of miR-411-5p and RYBP were found to be inversely correlated in HNSCC samples. In conclusion, the results of the present study indicated that the miR-411-5p-mediated downregulation of RYBP expression levels may exert an important role in HNSCC metastasis and may provide a novel target for the treatment of HNSCC.

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