期刊
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
卷 103, 期 -, 页码 395-401出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ijid.2020.12.011
关键词
COVID-19; Secondary attack rate; Children; Household contact
资金
- Foshan Scientific and Technological Key Project for COVID-19 [2020001000430]
- Science and Technology Plan Project of Guangzhou [201804010121]
- Project for Key Medicine Discipline Construction of Guangzhou Municipality [2017-2019-04]
The study found that children may be less susceptible to COVID-19, while close contacts with frequent contact with patients and those exposed to patients with cough symptoms have a higher risk of infection.
Objectives: This study aimed to compare the risk of infection of children with that of adults and to explore risk factors of infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) by following up close contacts of COVID-19 patients. Method: The retrospective cohort study was performed among close contacts of index cases diagnosed with COVID-19 in Guangzhou, China. Demographic characteristics, clinical symptoms and exposure information were extracted. Logistic regression analysis was employed to explore the risk factors. The restricted cubic spline was conducted to examine to the dose-response relationship between age and SARS-CoV-2 infection. Results: The secondary attack rate (SAR) was 4.4% in 1,344 close contacts. The group of household contacts (17.2%) had the highest SAR. The rare-frequency contact (p < 0.001) and moderate-frequency contact (p < 0.001) were associated with lower risk of infection. Exposure to index cases with dry cough symptoms was associated with infection in close contacts (p = 0.004). Compared with children, adults had a significantly increased risk of infection (p = 0.014). There is a linear positive correlation between age and infection (p = 0.001). Conclusions: Children are probably less susceptible to COVID-19. Close contacts with frequent contact with patients and those exposed to patients with cough symptoms are associated with an increased risk of infection. (C) 2020 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.
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