期刊
INTERNATIONAL JOURNAL OF CANCER
卷 149, 期 2, 页码 307-315出版社
WILEY
DOI: 10.1002/ijc.33535
关键词
antiepileptic drugs; HDAC inhibition; prostate cancer
类别
资金
- Academy of Finland [260931, 9V039]
- Academy of Finland (AKA) [260931, 260931] Funding Source: Academy of Finland (AKA)
The study found that men using antiepileptic drugs had a decreased overall risk of prostate cancer compared to non-users. This risk reduction was similar among users of HDAC inhibitors.
Antiepileptic drugs (AEDs) with histone deacetylase (HDAC) inhibitor properties decrease prostate cancer (PCa) cell proliferation in vitro. A population-based cohort of 78 615 men was used to evaluate the risk of PCa among users of AEDs. Study population was linked to the Finnish national prescription database to obtain information on individual medication reimbursements in 1996 to 2015. Cox regression with antiepileptic medication use as a time-dependent variable was used to analyze PCa risk overall, and low, medium and high-risk PCa separately. The analysis was adjusted for age, screening trial arm, and other drugs in use, including statins, antidiabetic drugs, antihypertensive drugs, aspirin, and nonsteroidal anti-inflammatory drugs. Compared to the nonusers of AEDs, overall PCa risk was decreased among AED users (hazard ratio [HR] = 0.86, 95% confidence interval [CI] = 0.76-0.96). A similar PCa risk decrease was observed among users of HDACi AEDs (HR = 0.87, 95% CI = 0.76-1.01), but no risk difference was found when comparing HDACi AED users to users of other AEDs (HR = 0.98, 95% CI = 0.76-1.27). Our study showed a decrease in overall PCa risk among men using AEDs compared to nonusers. The risk associations were similar for HDAC inhibitors as for AEDs in general.
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