期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 180, 期 -, 页码 458-469出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2021.02.209
关键词
Potato resistant starch; Diet-induced obesity; Intestinal microbiota; Metabolites; Intestinal barrier
资金
- Agricultural Science and Technology Innovation Program (CAAS-ASTIP-IFST)
- Agriculture Research System of China [CARS-09-27]
Potato resistant starch type 3 (PRS) can regulate high fat diet-induced metabolic syndrome, promote intestinal cell proliferation, reduce Firmicutes/Bacteroidetes ratio, regulate intestinal microbiota abundance and metabolites, and are associated with anti-obesity potential.
Potato resistant starch type 3 (PRS) is helpful for weight-loss. To investigate the regulatory effects of PRS on high fat diet (HFD)-induced obesity, different doses of PRS (5%, 15% and 25%) were fed to mice for 12 weeks. Metabolic syndrome related to obesity, intestinal microbiota composition and its metabolites as well as the relationship among them were studied. Results showed that PRS could regulate HFD-induced metabolic syndrome in a dose dependent manner; promote the proliferation of intestinal cells and expression of tight junction proteins, such as Occludin and zonula occludens (ZO)-1; reduce the Firmicutes/Bacteroidetes (F/B) rate; regulate the relative abundance of intestinal microbiota, such as Bifidobacterium, Ruminococcus, Bacteroides and Coprococcus; and promote the production of microbial metabolites, such as propionic acid and acetic acid. Besides, the alteration in the intestinal microbiota composition and metabolites were significantly correlated. It could be concluded that propionic acid and acetic acid were the two dominant metabolites of Bifidobacterium, Ruminococcus, Bacteroides, and Coprococcus, which contributed to the anti-obesity potential of PRS, metabolic syndrome alleviation, and intestinal barrier dysfunction. (c) 2021 Elsevier B.V. All rights reserved.
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