Synthesis of Ag@chitosan/copolymer with dual-active centers for high antibacterial activity

The prevention and treatment of microorganism contamination on substrate surfaces have recently generated significant concern of scientists. In this paper, a novel diblock copolymer containing antibacterial quaternary ammonium groups as pendant groups, poly(3-(methacryloylamino) propyltrimethyl ammonium chloride)-b-poly (styrene) (PMS), was synthesized by interfacial polymerization. Also, PMS anisotropic particles (APs) could be successfully obtained based on different assembly behaviors by adjusting the ratios of monomers and the toluene/styrene (Tol/St). Moreover, silver loaded chitosan (Ag@CS) and PMS APs were combined to prepare natural/synthetic polymer antibacterial materials with dual-active centers (Ag@CS/PMS-4 APs), aiming to expand the application of carbohydrate polymers and improve the antibacterial activity of composite materials. Remarkably, the resulting series of PMS particles, especially worm-like PMS-4 APs, and Ag@CS/PMS-4 APs composite film ((Ag@CS/PMS-4 APs)-F) exhibited excellent antibacterial properties, which can be employed as interface materials to prevent the transmission of infectious diseases caused by microorganism contamination. (C) 2021 Elsevier B.V. All rights reserved.

Automated summary

Scientists have recently shown significant concern in preventing and treating microorganism contamination on substrate surfaces. A novel diblock copolymer, PMS, containing antibacterial quaternary ammonium groups, was successfully synthesized by adjusting monomer ratios. The resulting PMS particles showed excellent antibacterial properties and could be used as interface materials to prevent the transmission of infectious diseases.