Tantalizing role of p53 molecular pathways and its coherent medications in neurodegenerative diseases

Neurodegenerative diseases are incongruous, commonly age-related disorders characterized by progressive neuronal loss, comprising the most prevalent being Alzheimer's disease, Parkinson's disease, and Huntington's disease. Perilous health states are anticipated following the neurodegeneration. Their etiology remains largely ambiguous, while various mechanisms are ascribed to their pathogenesis. A recommended conception is regarding the role of p53, as a transcription factor regulating numerous cellular pathways comprising apoptosis. Neuronal fates are a feasible occurrence that contributes to all neurodegenerative diseases. In this work, we review the research investigated the potential role of p53 in the pathogenesis of these diseases. We put special emphasis on intricate We not only describe aberrant changes in p53 level/activity observed in CNS regions affected by particular diseases but, most importantly, put special attention to the complicated reciprocal tuning connections prevailing between p53 and molecules considered in pathological hallmarks of these disorders. Natural and synthetic medications regulating p53 expression are regarded as well. (C) 2021 Elsevier B.V. All rights reserved.

Automated summary

Neurodegenerative diseases are age-related disorders characterized by progressive neuronal loss, with the most prevalent being Alzheimer's disease, Parkinson's disease, and Huntington's disease. The etiology remains largely ambiguous, but p53 is considered to play a significant role, regulating various cellular pathways including apoptosis.