Starch modified alginate nanoparticles for drug delivery application

Natural polymers have been widely studied as vehicles that have gained much interest in the encapsulation and delivery of drugs and bioactive molecules. In this study, we developed starch-modified alginate nanoparticles using a green facile technique for drug delivery application. The potential of the prepared nanoparticles for controlled drug delivery applications is demonstrated using theophylline and bovine serum albumin as model drugs. The nanoparticles possessed the encapsulation efficiency of 60 to 75%. The results of in vitro drug release studies showed the pH dependent characteristics of the prepared nanoparticles. In vitro cytotoxicity test revealed the biocompatibility of the developed nanoparticles against L929 fibroblast cell lines. The in vitro cellular uptake of nanoparticles was visualized in L929 fibroblast cells using fluorescent microscopy. The preliminary investigation suggests the developed nanoparticle is a promising candidate for drug delivery application. (C) 2021 Elsevier B.V. All rights reserved.

Automated summary

In this study, starch-modified alginate nanoparticles were developed for drug delivery application using a green facile technique. The nanoparticles demonstrated pH-dependent drug release characteristics and biocompatibility against L929 fibroblast cell lines. The preliminary investigation suggests the developed nanoparticles as a promising candidate for drug delivery application.