期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 169, 期 -, 页码 194-205出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2020.12.086
关键词
Soybean protein isolate; Fucoidan; Composite system; Curcumin
资金
- General Research Project of Education Department of Zhejiang Province [Y201942515]
- National Natural Science Foundation of China [21476212]
- Fundamental Research Funds for Zhejiang Provincial Universities and Research Institutes [2019J00004]
By embedding curcumin in core-shell nanoparticles using protein-polysaccharide complexes, the stability and dispersibility of Cur were effectively enhanced, providing a simple method for Cur delivery with potential applications for delivering lipid-soluble active ingredients.
Curcumin (Cur) is a natural polyphenol with beneficial biological and pharmacological activities; however, it has limited applications owing to its low solubility and light sensitivity. The protein-polysaccharide complex can effectively embed lipid-soluble drugs to increase their stability and dispensability in aqueous solutions. Soybean protein isolate (Spi) and fucoidan (Fuc) were used as a polymer matrix, and core-shell nanoparticles were prepared to encapsulate Cur via electrostatic interaction under acidic and neutral conditions. The structure of the Spi-Fuc nanoparticles was studied via Fourier-transform infrared spectroscopy, transmission electron microscopy, and scanning electron microscopy. Concurrently, we evaluated the efficacy of the nanoparticles based on stability, drug loading rate, and simulated release. Our results showed that the Spi-Fuc nanoparticles (size, approximately 236.56 nm) had a spherical, core-shell structure and that they could effectively load Cur with an embedding efficiency of >95%; moreover, the system had long-term dispersion stability. Thus, we provide a simple method for Cur delivery, which can also be potentially used for delivering lipid-soluble active ingredients. (C) 2020 Elsevier B.V. All rights reserved.
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