4.7 Review

An overview of Betacoronaviruses-associated severe respiratory syndromes, focusing on sex-type-specific immune responses

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Summary: Recent studies have shown that female COVID-19 patients have lower morbidity, severe case rate, and mortality compared to males. Nonmenopausal female patients had milder severity and better outcome, while menopausal patients had longer hospitalization times. Anti-Mullerian hormone (AMH) and estradiol (E2) were negatively correlated with COVID-19 severity, with E2 regulating cytokines related to immunity and inflammation.

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