期刊
INTERNATIONAL IMMUNOPHARMACOLOGY
卷 91, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.intimp.2020.107264
关键词
Bakuchiol In-vivo; In-vitro; RAW 264.7; BAK; Macrophages; Cell-mediated immunity; Humoral immunity; Phagocytic response; Immunomodulatory activities and Cytokines assay
资金
- CSIR-New Delhi [BSC-0205]
Bakuchiol (BAK) exhibits significant immunomodulatory and anti-inflammatory effects by suppressing pro-inflammatory cytokine expression and reducing hypersensitivity responses.
Bakuchiol (BAK) has been reported to have a diverse pharmacological property as an antibiotic, anti-cancer, antihypolipidemic, anti-inflammatory and anti-convulsant agent. This study aimed to elucidate the immunomodulation and anti-inflammatory mechanism of bakuchiol using lipopolysaccharide stimulated RAW 264.7 macrophages and various animal models. The present study has shown that BAK significantly suppressed the pro inflammatory cytokine expression in a dose-dependent manner and its oral administration significantly decreased delayed hypersensitivity responses as compared to control group. The assessment of immunomodulatory activity was carried out by the testing Hemagglutinating antibody (HA) titer, delayed type hypersensitivity (DTH) responses and phagocytic index by carbon clearance test. On the other hand, it showed significant decrease in circulating antibody titer and carbon clearance assay in a concentration-dependent manner. BAK has significantly potentiated the cellular immunity as well as humoral immunity by facilitating the footpad thickness responses in sheep RBCs in sensitized mice by significantly decreasing circulating antibody titer. Molecular studies revealed that BAK inhibited the activation of upstream mediator nuclear factor-kappa B by suppressing the phosphorylation of I kappa B alpha and p65. The responses were statistically significant as compared with the control (*p < 0.05, **p < 0.01).
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