期刊
INORGANIC CHEMISTRY COMMUNICATIONS
卷 125, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.inoche.2020.108404
关键词
Trioganotin(IV) complexes; 3,5-Bifluorobenzenetelluronic acid; Structural characterization; In vitro cytostatic activity; BSA-binding
资金
- National Natural Science Foundation of China [21371087]
- Natural Science Foundation of Shandong Province [ZR2017PB014]
Four novel 3,5-bifluorobenzenetelluronic triorganotin(IV) esters have been synthesized and characterized, showing different structural forms and cytotoxicity against human tumor cell lines. The compounds could quench the intrinsic fluorescence of BSA, suggesting potential biological applications.
Four novel 3,5-bifluorobenzenetelluronic triorganotin(IV) esters, namely (3,5-F2C6H3TeOH)(2)(mu-O)(2)(OSnR3)(4) (R = Me: 1, R = Ph: 2) and (3,5-F2C6H3TeOH)(OSnR3)4 (R = Me: 3, R = Ph: 4) have been synthesized and characterized by the reaction of deprotonated 3,5-bifluorobenzenetellumnic acid ligand and corresponding R3SnCl (R = Me, Ph). All the complexes have been characterized by means of elemental analysis, FT-IR, NMR (H-1, C-13, Sn-119) spectroscopy, and X-ray crystallography. Structural analyses of these complexes reveal that complexes 1 and 2 exhibit centrosymmetric dimeric structure with an almost planar four-membered Te-2(mu(2)-O)(2) core in the center, while 3 and 4 form monomeric structure with a single Te center. The Te atoms adopt octahedral geometry in all the complexes. Complexes 1-4 could form 2D or 3D supramolecular structures through intermolecular C-H center dot center dot center dot F or C-H center dot center dot center dot O interactions. Preliminary in vitro cytostatic studies show that complexes 1-4 exhibit effective cytostatic activity against human cervix adenocarcinoma cell lines (HeLa) and human hepatocellular carcinoma cell lines (HepG-2). For further assessing apoptosis properties of complex 2, the levels of apoptosis were examined. The BSA-binding properties were investigated by means of fluorescence titration. The results indicate that complexes 1-4 could quench the intrinsic fluorescence of BSA.
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