期刊
IMMUNOLOGY LETTERS
卷 233, 期 -, 页码 87-91出版社
ELSEVIER
DOI: 10.1016/j.imlet.2021.02.006
关键词
STAT6; B cells; IL-4
类别
资金
- Natural Science Foundation of Shanghai [18ZR1429900]
- General Program of National Natural Science Foundation of China [81771736, 81971493]
- Shanghai Rising-Star Program [20QA1407900]
- Innovative Research Team of High-level Local Universities in Shanghai [GS4]
This article systematically summarizes the crucial role of STAT6 in promoting the development of B cells and immune function, as well as the potential health issues that may arise from STAT6 deficiency.
Signal transducers and activators of transcription (STATs) family of proteins are the key signal molecules in the JAK-STAT classical activation pathway of cell biology. STAT6, as a member of the STATs family, is principally activated by IL-4 and IL-13. In addition to Th2 cell differentiation, it plays a crucial role in promoting the development, differentiation, and class switching of B cells. STAT6 deficiency leads to impaired immune function, decreased glycolysis, and morphological changes in B cells, which will help develop various diseases. In this review, we will systematically summarize the major findings of how STAT6 regulates B cells to reveal the potential of STAT6 in treating human diseases.
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