期刊
HUMAN IMMUNOLOGY
卷 82, 期 5, 页码 346-352出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.humimm.2021.01.019
关键词
cytotoxic T cell; Pregnancy; Miscarriage; Preeclampsia; regulatory T cell
类别
资金
- Ministry of Education, Culture, Sports, Science and Technology in Japan (KAKENHI) [19 K18690]
- Tamura Science & Technology Foundation, Toyama, Japan
- First Bank of Toyama Scholarship Foundation Research Grant, Toyama, Japan
- AMED [JP20gk011004]
Fetal antigen-specific tolerance is crucial for maintaining allogeneic pregnancies, with a key role played by Treg cells. Insufficient or dysfunctional Treg cells may contribute to the pathogenesis of complications such as miscarriage and preeclampsia in pregnancy.
Fetal antigen-specific tolerance is important for maintaining allogeneic pregnancies. Maternal conventional T cells recognize fetal antigens; however, regulatory T (Treg) cells suppress immune reactions against the fetus. Fetal antigen-specific Treg cells are induced in the decidua upon contact with antigen-presenting cells and extravillous trophoblasts (EVTs). Functional alteration of cytotoxic T cells (CTLs) in the decidua also contributes to maintaining the pregnancy. Reduced, dysfunctional, and imbalanced Treg cell distribution likely contributes to the pathogenesis of pregnancy complications, such as miscarriage and preeclampsia. Recent studies have revealed differences in Treg cell characteristics during preeclampsia and miscarriage. Treg cell reduction in the decidua is likely associated with miscarriage. Insufficient expansion of fetal antigen-specific Treg cells in the decidua probably plays a role in preeclampsia pathogenesis. In addition, the balance between Treg cell-mediated tolerance and functional alteration of CTLs is important. Further investigations of functional molecules in Treg cells will contribute to the development of immunotherapy for pregnancy complications. (c) 2021 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
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