Synthesis of Enantiopure Benzo Fused Cyclic Sulfoximines Through Stereoselective [3+2] Cycloaddition between N-tert-Butanesulfinyl [(2-Pyridyl)sulfonyl]-difluoromethyl Ketimines and Arynes

The previously developed stereoselective [3+2] cycloaddition between N-tert-butanesulfinyl ketimines and arynes has been extended to the synthesis of enantiopure [(2-pyridyl)sulfonyl]difluoromethylated cyclic sulfoximines. The use of 2-PySO2CF2 as the facilitating group offers new opportunities for the elaboration of the [3+2] cycloaddition products by virtue of the diverse relativity of 2-pyridyl sulfones.

Automated summary

The stereoselective [3+2] cycloaddition reaction between N-tert-butanesulfinyl ketimines and arynes has been successfully extended to the synthesis of enantiopure [(2-pyridyl)sulfonyl]difluoromethylated cyclic sulfoximines. The use of 2-PySO2CF2 as a facilitating group has opened up new opportunities for further research due to the diverse relativity of 2-pyridyl sulfones.