期刊
GENES & DEVELOPMENT
卷 35, 期 5-6, 页码 329-334出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.346460.120
关键词
in vivo bioluminescence recording; liver; suprachiasmatic nucleus; circadian gene expression
资金
- Swiss National Science Foundation (SNSF) [31-113565, 31-128656/1]
- European Research Council [ERC-2009-AdG-TIMESIGNAL-250117]
- State of Geneva
- Louis Jeantet Foundation of Medicine
- Swiss Society of Endocrinology and Diabetology (SGED) Young Investigator grant
- SNSF [31003A_146694, 31003A_166700/1, 310030_184708/1]
- Vontobel Foundation
- Novartis Consumer Health Foundation
- Swiss Life Foundation
- European Foundation for the Study of Diabetes/Novo Nordisk Program for Diabetes Research in Europe
- Olga Mayenfisch Foundation
- National Institutes of Health [NS055831]
- State of Vaud
- Center of Biomedical Research and Education (ZBAF) at Witten/Herdecke University
The study suggests that the suprachiasmatic nucleus is necessary for synchronizing organs, but even in the absence of the suprachiasmatic nucleus or other cellular oscillators, the livers of mice still exhibit circadian rhythms.
It has been assumed that the suprachiasmatic nucleus (SCN) synchronizes peripheral circadian oscillators. However, this has never been convincingly shown, since biochemical time series experiments are not feasible in behaviorally arrhythmic animals. By using long-term bioluminescence recording in freely moving mice, we show that the SCN is indeed required for maintaining synchrony between organs. Surprisingly, however, circadian oscillations persist in the livers of mice devoid of an SCN or oscillators in cells other than hepatocytes. Hence, similar to SCN neurons, hepatocytes can maintain phase coherence in the absence of Zeitgeber signals produced by other organs or environmental cycles.
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