期刊
FREE RADICAL BIOLOGY AND MEDICINE
卷 163, 期 -, 页码 306-313出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2020.12.022
关键词
1267 nm; Singlet oxygen; Energy metabolism; Mitochondrial respiration; Brain
资金
- Engineering and Physical Sciences Research Council (EPSRC) [EP/R024898/1]
The study found that singlet oxygen generated by 1267 nm laser pulse can activate mitochondrial respiration in neurons and astrocytes, leading to increased ATP production in these cells.
Oxygen, in form of reactive oxygen species (ROS), has been shown to participate in oxidative stress, one of the major triggers for pathology, but also is a main contributor to physiological processes. Recently, it was found that 1267 nm irradiation can produce singlet oxygen without photosensitizers. We used this phenomenon to study the effect of laser-generated singlet oxygen on one of the major oxygen-dependent processes, mitochondrial energy metabolism. We have found that laser-induced generation of O-1(2) in neurons and astrocytes led to the increase of mitochondrial membrane potential, activation of NADH- and FADH-dependent respiration, and importantly, increased the rate of maximal respiration in isolated mitochondria. The activation of mitochondrial respiration stimulated production of ATP in these cells. Thus, we found that the singlet oxygen generated by 1267 nm laser pulse works as an activator of mitochondrial respiration and ATP production in the brain.
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