4.5 Article

Fatal pyrrolizidine alkaloid poisoning of infants caused by adulterated Senecio coronatus

期刊

FORENSIC SCIENCE INTERNATIONAL
卷 320, 期 -, 页码 -

出版社

ELSEVIER IRELAND LTD
DOI: 10.1016/j.forsciint.2020.110680

关键词

Senecio coronatus; LCMS; UPLC-MS; MS; Retrorsine-N-oxide; Pyrrolizidine alkaloids; Traditional medicine

资金

  1. National Research Foundation of South Africa (NRF Grant) [84442]
  2. University of Johannesburg
  3. Stellenbosch University

向作者/读者索取更多资源

Senecio coronatus, commonly used in traditional medicine in South Africa, does not contain pyrrolizidine alkaloids. Fatal cases of hepatic sinusoidal obstruction syndrome in infants were caused by wrongly identified Senecio species containing large amounts of retrorsine-N-oxide. A validated UPLC-MS/MS method for detecting and quantifying pyrrolizidine alkaloids is described.
Senecio coronatus (known as izonkozonko and ubulibazi in Zulu) is commonly used in traditional medicine in South Africa as purification purgative and enemas for infants during weaning. We show for the first time that this species does not contain pyrrolizidine alkaloids and that reported cases of fatal hepatic sinusoidal obstruction syndrome in infants were caused by wrongly identified Senecio species containing large amounts of retrorsine-N-oxide. A validated ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method for the detection and quantitation of pyrrolizidine alkaloids is described. (c) 2021 Elsevier B.V. All rights reserved.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据