期刊
FOOD AND CHEMICAL TOXICOLOGY
卷 151, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2021.112116
关键词
ELISA; LC/MS-MS; Monte; Carlo simulation; MOE; HCC risk
资金
- European Union [678781]
- Ministry of Education, Science and Technological Development of the Republic of Serbia [TR31034]
The study analyzed the exposure to aflatoxin B1 (AFB1) in commonly consumed foods in Serbia, finding that children had the highest exposure levels, raising concerns for their health. The Margin of Exposure (MOE) calculation and estimation of potential hepatocellular carcinoma (HCC) cases revealed low MOE values and a range of possible HCC cases per year based on population groups.
Classified as Group 1 carcinogens aflatoxins (AFs) are of major concern for food safety and public health. Within the AFs group, aflatoxin B1 (AFB1) occurs at the highest levels in different food products and is considered as the most potent representative. A total of 463 samples of products susceptible to contamination with AFB1 and commonly consumed in Serbia were collected and analyzed. Consumption surveys were performed using a food frequency questionnaire (FFQ) and 24-h recall-based method. Monte Carlo simulation of 100,000 iterations was performed to estimate the intake of AFB1 through each food category, while a simple distribution approach was performed to estimate overall exposure of tested population groups. Risk characterization was performed by calculation of the Margin of Exposure (MOE) and by calculation of the number of possible hepatocellular carcinoma (HCC) cases. The highest exposure was observed in children with the mean overall estimated daily intake (EDI) in the range of 0.79-1.10 and 1.20-1.66 ng kg(-1) bw day(-1), followed by adolescents 0.56-0.81 and 0.94-1.32 ng kg(-1) bw day(-1), adult females 0.52-0.72 and 0.56-0.76 ng kg(-1) bw day(-1) and adult males with the mean overall EDI in the range of 0.39-0.56 and 0.47-0.66 ng kg(-1) bw day(-1) depending on consumption survey method and for the lower (LB) and upper bound (UB) scenario. MOE values that resulted from the mean values of the overall EDI of AFB1 were low, indicating high concern for all population groups. Based on obtained mean values of the overall EDI higher estimates of possible HCC cases caused by exposure to AFB1 were in the range of 0.01-0.02 cases/year/10(5) individuals, depending on the population group.
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