期刊
FERTILITY AND STERILITY
卷 115, 期 6, 页码 1549-1556出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2020.12.019
关键词
Antibiotic; CD138; chronic endometritis; rate of negative test results
资金
- National Key Research and Development Program of China [2018YFC1004800]
- Sea Poly Project of Beijing Overseas Talents
The study compared the rates of negative test results for chronic endometritis (CE) in patients who received antibiotic treatment and those who did not. The results showed that a 14-day course of broad-spectrum oral antibiotic therapy was effective in treating CE in over 89.8% of cases, but its impact on pregnancy outcomes remains uncertain.
Objective: To compare the rates of negative test results for chronic endometritis (CE) between subjects who did and did not receive antibiotic treatment. Design: Prospective, single-blind randomized controlled trial. Setting: Tertiary hysteroscopic center in a university teaching hospital. Patient(s): A total of 132 women with CE confirmed with immunohistochemical study with CD138 epitope. Intervention(s): Women randomized to antibiotic therapy received oral levofloxacin 500 mg and tinidazole 1,000 mg daily for 14 days. Women randomized to the control group did not receive any treatment. A repeated endometrial biopsy was performed 4 to 8 weeks after the initial biopsy to determine whether CE was still present. Main Outcome Measure(s): The rate of negative test results for CE (from positive to negative). Result(s): The CE rate of negative test results in the treatment group (89.3%) after one course of antibiotic treatment was significantly higher than that in the control group (12.7%). Among subjects who attempted pregnancy, there was no significant difference in ongoing pregnancy rates and miscarriage rates between the treatment arm (43.2%, 5.4%) and the control arm (25.7%, 14.3%). Among subjects randomized, there was also no significant difference in ongoing pregnancy rates and miscarriage rates between the treatment arm (27.1%, 3.4%) and the control arm (16.4%, 9.1%). Conclusion: A course of broad-spectrum oral antibiotic therapy for 14 days is effective in the treatment of CE in >89.8% of cases. However, it is not yet clear whether treatment improved pregnancy outcomes. (C) 2020 by American Society for Reproductive Medicine.
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