4.3 Review

Safety considerations selecting antiseizure medications for the treatment of individuals with Dravet syndrome

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Review Clinical Neurology

Practical use of pharmaceutically purified oral cannabidiol in Dravet syndrome and Lennox-Gastaut syndrome

Simona Lattanzi et al.

Summary: Pharmaceutically purified oral cannabidiol (CBD) has been approved for treating seizures associated with Dravet syndrome (DS) and Lennox-Gastaut syndrome (LGS), showing efficacy in managing symptoms such as somnolence, gastrointestinal discomfort, and increase in serum transaminases. CBD's metabolism in the liver can influence drug metabolism enzymes, particularly in interactions with antiseizure medications like clobazam. The findings pertain specifically to high-grade purified CBD oral solution and may not be applicable to other cannabis-based products.

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