期刊
EXPERIMENTAL EYE RESEARCH
卷 204, 期 -, 页码 -出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exer.2021.108455
关键词
Diabetic cornea; Graves? disease; Addison?s disease; SARS-CoV-2; Herpes; Zoster; Tuberculosis; Syphilis; Pseudomonas aeruginosa; Autoimmune disease; Inflammation; Keratoconjunctivitis; Genetic corneal disease; Corneal deposit disorder; Aniridia; Ehlers-Danlos syndrome; Marfan syndrome; Immunobullous disease
资金
- NIH [R01 EY013431, EY031377, EY029160, EY025377, EY029829, EY013615, EY024649, EY026944, EY026964, EY027381]
- CIRM [TRAN1COVID19-11975]
- Board of Governors Regenerative Medicine Institute
Systemic diseases can affect the cornea, with corneal manifestations providing insights into other underlying health conditions and potentially serving as the first indicator of undiagnosed systemic diseases. Routine eye exams can help detect potential life-threatening illnesses.
There is a number of systemic diseases affecting the cornea. These include endocrine disorders (diabetes, Graves? disease, Addison?s disease, hyperparathyroidism), infections with viruses (SARS-CoV-2, herpes simplex, varicella zoster, HTLV-1, Epstein-Barr virus) and bacteria (tuberculosis, syphilis and Pseudomonas aeruginosa), autoimmune and inflammatory diseases (rheumatoid arthritis, Sjo?gren?s syndrome, lupus erythematosus, gout, atopic and vernal keratoconjunctivitis, multiple sclerosis, granulomatosis with polyangiitis, sarcoidosis, Cogan?s syndrome, immunobullous diseases), corneal deposit disorders (Wilson?s disease, cystinosis, Fabry disease, Meretoja?s syndrome, mucopolysaccharidosis, hyperlipoproteinemia), and genetic disorders (aniridia, Ehlers-Danlos syndromes, Marfan syndrome). Corneal manifestations often provide an insight to underlying systemic diseases and can act as the first indicator of an undiagnosed systemic condition. Routine eye exams can bring attention to potentially life-threatening illnesses. In this review, we provide a fairly detailed overview of the pathologic changes in the cornea described in various systemic diseases and also discuss underlying molecular mechanisms, as well as current and emerging treatments.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据