期刊
EXPERIMENTAL EYE RESEARCH
卷 206, 期 -, 页码 -出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exer.2021.108520
关键词
Short chain fatty acids; Intraocular inflammation; Danger signals; Retinal astrocytes; Cytokines; T cell activation
资金
- National Institutes of Health [EY024051]
- Research to Prevent Blindness (RPB)
- Commonwealth of Kentucky Research Challenge Trust Fund
- Sullivan University College of Pharmacy
Short chain fatty acids (SCFAs) are produced by gut microbiota and can affect inflammatory responses in the eye and retinal astrocytes. They may cross the blood-eye-barrier via the systemic circulation and impact cellular functions in the intraocular milieu.
Short chain fatty acids (SCFAs) are produced by gut microbiota as fermentation products of digestion-resistant oligosaccharides and fibers. Their primary roles are functioning as major energy sources for colon cells and assisting in gut homeostasis by immunomodulation. Recent evidence suggests that they affect various organs both at cellular and molecular levels, and regulate functions in distance sites including gene expression, cell proliferation, cell differentiation, apoptosis and inflammation. In this study, we examined whether SCFAs are present in the mouse eye and whether SCFAs affect inflammatory responses of the eye and retinal astrocytes (RACs). We observed that intra-peritoneal injected SCFAs were detected in the eye and reduced intraocular inflammation induced by lipopolysaccharide (LPS). Moreover, SCFAs displayed two disparate effects on LPSstimulated RACs ? namely, cytokine and chemokine production was reduced, but the ability to activate T cells was enhanced. Our results support the existence of gut-eye cross talk and suggest that SCFAs can cross the bloodeye-barrier via the systemic circulation. If applied at high concentrations, SCFAs may reduce inflammation and impact cellular functions in the intraocular milieu.
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