期刊
EXPERIMENTAL CELL RESEARCH
卷 402, 期 1, 页码 -出版社
ELSEVIER INC
DOI: 10.1016/j.yexcr.2021.112551
关键词
lncRNA DLEU2; Cervical cancer; Cell proliferation; Cell cycle; NOTCH pathway
资金
- Key Research and Development of Social and People's Livelihood [cstc2018jscx-mszdX0031]
- Natural Science Foundation of Chongqing in China [cstc2019jcyj-msxmX0259]
The study identified that lncRNA DLEU2 is significantly upregulated in cervical cancer tissues, promoting cell proliferation and accelerating the cell cycle. Through mechanisms such as inhibiting p53 expression, lncRNA DLEU2 may promote cell cycle progression by inhibiting the activity of the Notch signaling pathway.
Long noncoding RNAs (lncRNAs) are known to play a crucial role in the onset and progression of cervical cancer (CC). Here, the results of RNA microarray and RNA-sequencing dataset analysis showed that lncRNA DLEU2 was significantly upregulated in CC tissues. Clinicopathologic analysis indicated that lncRNA DLEU2 was closely related to tumor topography. Functional experiments and bioinformatics analysis revealed that lncRNA DLEU2 promoted CC cell proliferation and accelerated the cell cycle. Mechanistically, lncRNA DLEU2 promoted the progression of the cell cycle and inhibited the activity of the Notch signaling pathway by inhibiting p53 expression. Additionally, lncRNA DLEU2 probably interacted with ZFP36 Ring Finger Protein (ZFP36) to inhibit the expression of p53. In conclusion, this study revealed the function of lncRNA DLEU2 in CC tumorigenesis, suggesting new therapeutic targets in CC.
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