Star-hyperbranched waterborne polyurethane based on D-glucose-poly (ε-caprolactone) core as a biomaterial candidate

Herein, a novel three-dimensional (3D) waterborne poly (ester-urethane-urea) (WPEUU) networks containig Dglucose-poly(epsilon-caprolactone) (GBPS) as a pentol star core were designed and synthesized. The structure and properties of the polymers were investigated by FTIR and (HNMR)-H-1 spectroscopy methods and FE-SEM, DSC and TGA techniques in detail. In addition, the degree of polymerization (DPn = 12), the number average molecular weight (M-n similar to 7000 g/mol) and funtionality (f = 5) of pentol star were controlled and determined by means of (HNMR)-H-1. Physico-chemical characterization revealed that WPEUU compared with GBPS, showed a decrease in the degree of crystallinity (from X-c similar to 42% to X-c similar to 20%) and water contact angle (77.3 degrees to 36.4 degrees), which presented higher hydrophilicity, degradability and compatibility in vitro (14% VS 6% mass loss) and in vivo (30% weight loss) after four weeks degradation. The in vivo and in vitro degradations phenomen and surface morphology changes were compared by using FESEM micrographs. The skinny fibrous capsules (similar to 5-7 mu m) were observed around the WPEUU films. These results and low cytotoxicity to the L929 cells, also can be deduced that the prepared biodegradable and biocompatible WPEUU can be employed as potential biomaterial for biomedical applications in the future.

Automated summary

In this study, a novel three-dimensional waterborne polymer network containing a pentol star core was designed and synthesized. The polymer showed increased hydrophilicity, degradability, and biocompatibility compared to the core material. These results suggest that the prepared polymer has potential for biomedical applications in the future.