期刊
EUROPEAN JOURNAL OF PHARMACOLOGY
卷 893, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.ejphar.2020.173810
关键词
Apigenin; Hepatocellular carcinoma; Wnt/beta-catenin; Apoptosis; H19
资金
- National Natural Science Foundation of China [81773066, 81772404]
- Natural Science Foundation of Guangdong Province [2020A1515010961]
The research demonstrates that apigenin (API) can suppress tumor growth of hepatocellular carcinoma (HCC) by down-regulating the H19-mediated Wnt/beta-catenin signaling pathway.
Hepatocellular Carcinoma (HCC) is one of the leading causes of cancer-related deaths in the world. However, the effective pharmacological approaches remain scanty in clinical practice. As a bioactive flavonoid, apigenin (API) is enriched in common fruits and vegetables. Although pharmacological activities of API have been widely investigated, its biological function in HCC remains obscure. In the present study, we found that API strongly suppressed cell growth and induced apoptosis in HCC cells. Using a xenograft mice model, API was demonstrated to inhibit the in vivo tumor growth. It is known that the long non-coding RNA H19, which is frequently elevated in HCC, plays a vital role in mediating tumorigenesis and cancer progression. Our results demonstrated that H19 was down-regulated by API, and thereby induced the inactivation of the canonical Wnt/beta-catenin signaling. In conclusion, our results demonstrated that API was able to suppress tumor growth of HCC through H19-mediated Wnt/beta-catenin signaling regulatory axis, suggesting that API may be a promising candidate for developing novel therapeutic approaches against liver cancer.
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