期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2021, 期 11, 页码 1720-1725出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.202001673
关键词
π -Acids; Amination; Homogeneous catalysis; Oxidations; Selenium
资金
- European Research Council (ERC Starting Grant ELDORADO) [803426]
- Lower Saxony Ministry for Science and Culture (Georg-Christoph-Lichtenberg Fellowship)
- Projekt DEAL
- European Research Council (ERC) [803426] Funding Source: European Research Council (ERC)
The facile synthesis of aminoallenes through a selenium-pi-acid-catalyzed cross-coupling of N-fluorinated sulfonimide with simple alkynes has been achieved. This method offers a simple and efficient way to construct the aminoallene motif using ordinary internal alkynes as precursors, tolerating various functional groups and providing the target compounds in up to 86% yield.
The facile synthesis of aminoallenes, accomplished by a selenium-pi-acid-catalyzed cross-coupling of an N-fluorinated sulfonimide with simple, non-activated alkynes, is reported. Until now, aminoallenes were difficult to be accessed by customary means, inasmuch as pre-activated and, in part, intricate starting materials were necessary for their synthesis. In sharp contrast, the current study shows that ordinary internal alkynes can serve as simple and readily available precursors for the construction of the aminoallene motif. The operating reaction conditions tolerate numerous functional groups such as esters, nitriles, (silyl)ethers, acetals, and halogen substituents, furnishing the target compounds in up to 86 % yield.
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