期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2021, 期 11, 页码 1643-1646出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.202100095
关键词
All-carbon quaternary stereocenters; Cyanation; Diarylmalononitriles; para-Quinone methides; Trifluoromethyl
资金
- National Science Foundation of China [21971148, 21977021, 81760626]
An efficient construction of diarylmethanes containing CF3- and CN-substituted all-carbon quaternary stereocenters has been achieved via cyanation of delta-CF3-delta-aryl disubstituted para-quinone methides. The method shows broad scope, high efficiency, and enables rapid access to valuable CF3-substituted di- and triarylmethanes. Additionally, cyanation of delta-CN-substituted para-quinone methides furnishes diarylmalononitriles in good yields, demonstrating the generality of the approach.
An effective construction of diarylmethanes containing CF3- and CN-substituted all-carbon quaternary stereocenters via cyanation of delta-CF3-delta-aryl disubstituted para-quinone methides has been described. The reaction proceeds smoothly under simple and mild conditions and exhibits a broad scope of delta-CF3-delta-aryl disubstituted para-quinone methides in high efficiency. delta-CF3-delta-alkynyl-disubstituted para-quinone methides also proved to be suitable substrates. The rich chemistry of the cyano moiety allows for rapid access to other valuable CF3-substituted di- and triarylmethanes containing all-carbon quaternary centers that are otherwise difficult to synthesize. The generality of the method was further demonstrated by cyanation of delta-CN-substituted para-quinone methides furnishing diarylmalononitriles in good yields.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据