Diaryliodonium Salts in Transition-Metal-Catalyzed Chelation-Induced C(sp2/sp3)-H Arylations

Transition-metal-catalyzed Cross-coupling via directing group assisted C-H bond activation has become an expedient tool in current synthesis to achieve diverse molecular complexity. In this context, chelation-assisted arylations of C(sp(2)/sp(3))-H bonds have been extensively investigated as aryl/biaryl derivatives are an important contributor in the area of the industry, farming, medicinal and material science. The diaryliodonium salt has been broadly utilized in C(sp(2)/sp(3))-H bond arylation where the reaction proceeds via oxidative addition of aryliodonium salt to chelation induced metallacycle. The proximal/remote C(sp(2)/sp(3))-H bonds in coordination with transition metals are arylated by a range of directing groups in good to excellent yields. In this mini-review, we have outlined the up to date developments on transition-metal-catalyzed chelation assisted C(sp(2)/sp(3))-H bond arylation utilizing diaryliodonium salts as the coupling partner.

Automated summary

Transition-metal-catalyzed chelation assisted C(sp(2)/sp(3))-H bond arylation using diaryliodonium salts as coupling partners is an efficient method to achieve molecular diversity. By introducing aryl or biaryl derivatives, it can play an important role in industries, agriculture, medicinal, and material science.